Feline eosinophilic granuloma complex yog ib qho pab pawg ntawm cov kab mob sib kis hauv miv uas tuaj yeem nthuav tawm peb hom kev kho mob: indolent ulcer, eosinophilic plaque thiab eosinophilic granuloma. Lawv tau ua los ntawm cov keeb kwm zoo sib xws, qhov mob uas muaj ntau eosinophils (cov cell uas cuam tshuam rau lub cev tiv thaiv kab mob, kev tsis haum tshuaj lossis cov txheej txheem inflammatory, thiab lwm yam), nrog rau qhov mob plab yog ib qho uas nthuav tawm tsawg kawg nkaus, thiab. tsis khaus lossis mob. Degeneration ntawm collagen cov ntaub so ntswg yog pom nyob rau hauv cov ntaub ntawv ntawm eosinophilic granuloma, thiab eosinophilic plaque yog khaus heev nyob rau hauv cov miv cuam tshuam. Qhov kev kuaj pom tseeb uas yuav sib txawv ntawm lwm cov kab mob uas muaj cov kab mob zoo sib xws yuav yog histopathology, raws li kev kuaj ntshav, txawm tias cytology kuj tseem muaj txiaj ntsig zoo rau tib yam.
feline eosinophilic granuloma complex yog dab tsi?
Eosinophilic granuloma complex muaj xws li ib pawg heterogeneous ntawm cutaneous, mucocutaneous thiab qhov ncauj kab noj hniav, uas yog cov qauv ntawm daim tawv nqaij cov tshuaj tiv thaiv uas tshwm sim los ntawm underlying hypersensitivities. Histopathologically thiab kho mob, lawv tau muab faib ua peb hom: eosinophilic plaque, eosinophilic granuloma thiab indolent ulcer Cov ntaub ntawv kho mob no tuaj yeem tshwm sim hauv tib lub miv ib zaug lossis ua tiav..
Nyob rau hauv tag nrho cov ntaub ntawv, feem ntau eosinophilic tivthaiv yog muaj nyob rau hauv cov ntaub so ntswg, vim yog ib tug chemotactic los yog attraction ua los ntawm tej yam kab mob, nrog rau cov kab mob, kab mob xws li fleas los yog hypersensitivity tshua xws li atopic dermatitis, Cov tshuaj tiv thaiv tsis zoo rau zaub mov los yog yoov tshaj cum los yog yoov tshaj cum. Raws li qhov tshwm sim, cov tshuaj tiv thaiv kab mob tshwm sim nrog kev ua haujlwm ntawm eosinophils uas yuav ua rau cov tshuaj tiv thaiv tsis tu ncua, uas yuav ua rau muaj kev tsim cov pob txha nrog eosinophil granules, uas tso tawm cov ntsiab lus tseem ceeb lossis cationic cov protein thiab ua rau qee zaum, rau collagen necrosis.
Cov tsos mob ntawm eosinophilic granuloma complex hauv miv
Raws li peb hais, feem ntau yog los ntawm peb hom, yog li peb yuav nthuav dav cov tsos mob uas tus miv tuaj yeem tshwm sim hauv ib qho ntawm lawv:
Eosinophilic plaque cov tsos mob
Nws yog daim ntawv kho mob pruritic tshaj plaws (nws ua rau khaus heev), tshwj xeeb tshaj yog cuam tshuam rau miv ntawm hnub nyoog 2 txog 6 xyoo thiab tsuas yog txwv rau thaj chaw ventral xws li lub plab, lub ntsej muag sab hauv. ntawm tus ncej puab lossis puab tsaig thiab tej zaum yuav muaj nrog o ntawm cov qog ntshav Nws feem ntau tshwm sim nyob rau lub caij nplooj ntoo hlav vim muaj kev hnov mob rau yoov tshaj cum lossis ib puag ncig ua xua, thiab nrog rau cov zaub mov tsis haum.
cov kab mob yog oval los yog voj nyob rau hauv cov duab, tsis muaj plaub hau thiab nrog circumscribed ciam teb, yooj yim los yog multifocal, heev inflammatory, khaus, reddened thiab lawv tsim plaques nrog ntau exudation uas ua rau miv tsis txhob licking.
Eosinophilic granuloma cov tsos mob
Kuj hu ua linear los yog collagenolytic granuloma, qhov chaw cuam tshuam raug kev puas tsuaj collagen. Cov kab mob tsis zoo li pruritic los yog predisposed nyob rau hauv txhua haiv neeg, hnub nyoog, los yog poj niam txiv neej. Lawv feem ntau pom tau tias yog tsa alopecic kab ntawm cov kab mob, liab thiab grainy nyob rau hauv tsos ntawm lub posterior ncej, nyob rau hauv ib tug qauv txuam nrog miv tu.
Lwm qhov chaw yog lub puab tsaig, sab di ncauj, qhov ncauj kab noj hniav thiab txawm lub qhov ntswg, muzzle thiab cov pob qij txha ntawm cov ntaub qhwv thiab daim tawv nqaij ntawm tus ntiv tes. Cov nodules ntawm lub qhov ncauj kab noj hniav feem ntau pom ntawm tus nplaig los yog palate thiab dawb foci tej zaum yuav pom tau hais tias sib haum mus rau qhov chaw uas muaj collagen puas lawm thiab feem ntau tsis cuam tshuam nrog zom thiab apprehension.
Tseem hu ua eosinophilic ulcer thiab feem ntau cuam tshuam rau cov poj niam hnub nyoog 5 txog 6 xyoo, txwv rau mucocutaneous hlws ris ntawm daim di ncauj sab sauv Lawv Cov txheej txheem zoo, ci ntsa iab, alopecic lesions uas tuab thiab nce xim (erythema), muab rau lawv "cov nqaij ua noj" tsos thiab txawm ulceration. Txawm li cas los xij, txawm tias lawv qhov tsos tsis zoo, lawv tsis ua rau mob lossis khaus.
Tej zaum yuav pib nrog ib pob me me uas ua rau mob thiab kis mus rau qhov ntswg, tshwj xeeb tshaj yog tias tus miv rov licks nws tus kheej, ua rau muaj kev puas tsuaj ntau dua li raug mob. Muaj qee qhov pov thawj tias nws yuav yog vim muaj kev tsis haum rau dev mub lossis lwm yam tshuaj ua xua, tab sis nyob rau hauv ntau zaus nws tsis tuaj yeem paub qhov ua rau thiab nws raug cais raws li "idiopathic".
Kev kuaj mob ntawm feline eosinophilic granuloma complex
Pom cov kab mob ntawm eosinophilic granuloma complex hauv miv tsis feem ntau muaj ntau yam teeb meem thiab nrog cov ncauj lus kom ntxaws anamnesis thiab keeb kwm kho mob, qhov ua rau muaj kev tsis haum tuaj yeem raug txiav txim siab. A differential diagnosis yuav tsum ib txwm ua nrog rau lwm yam kab mob ntawm daim tawv nqaij los yog muaj peev xwm ua rau mob zoo ib yam li indolent ulcers los yog ulcers thiab granulomas ntawm feline qhov ncauj kab noj hniav, xws li:
- Mastocytoma.
- Squamous cell carcinoma.
- Herpesvirus.
- Calicivirus.
- Cryptococcosis.
- Pemphigus vulgaris.
- Lymphosarcoma.
- Fibrosarcoma.
- Plasmacocyte stomatitis.
kab lis kev cai ntawm kab mob thiab kev soj ntsuam susceptibility tej zaum yuav ua tau kom muab cov ntaub ntawv ntau ntxiv txog kab mob keeb kwm thiab cov tshuaj tua kab mob tsim nyog rau kev kho mob. Ntawm qhov tod tes, daim tawv nqaij scrapings tso cai rau tus kab mob parasitic los txiav tawm. Tsis tas li ntawd, hauv kev kuaj ntshav, tshwj xeeb tshaj yog nyob rau hauv eosinophilic granuloma lossis plaque, tej zaum yuav muaj eosinophilia (nce eosinophil suav).
LUB ZAUB MOV NOJ, YUAV UA LI CAS, yuav tsum tau ua rau kev tshuaj xyuas thiab kuaj pom ntawm kev hloov pauv tau cuam tshuam nrog feline eosinophilic granuloma complex lesions:
- Nyob hauv cytology ntawm cov kab mob categorized li plaque los yog eosinophilic granuloma, macrophages thiab eosinophils yuav ua pov thawj, thaum lub qhov txhab tsis muaj zog yuav tsis. ntau heev ntawm eosinophils, tab sis ntau macrophages thiab kab mob.
- Nyob hauv tawv nqaij biopsy, histopathological kuaj pom, nyob rau hauv cov ntaub ntawv ntawm eosinophilic granuloma, granulomatous o nrog focal thaj chaw ntawm collagen degeneration ncig los ntawm eosinophils ntau, ua raws li tus lej me me ntawm macrophages thiab mast cells thiab palisade multinucleated giant cells. Nyob rau hauv cov ntaub ntawv ntawm eosinophilic plaque, spongiotic o yog pom nyob rau hauv lub dermis thiab ib tug predominance ntawm eosinophils uas yuav txuas mus rau cov ntaub so ntswg subcutaneous; mast cells, macrophages, thiab lymphocytes kuj tuaj yeem tshwm sim, tab sis tsawg dua. Nyob rau hauv qhov mob plab, diffuse infiltrates ntawm eosinophils yuav raug soj ntsuam ua ke nrog neutrophils, macrophages thiab mast hlwb, tab sis nyob rau ntau lub sij hawm biopsies tau ua nyob rau hauv lub sij hawm ntev thiab lymphocytes, plasma hlwb, neutrophils (ntau dua qhov ntau dua ntawm qhov mob), yuav. pom, macrophages thiab fibrosis. Kev tsom xam histopathological yog qhov tseem ceeb heev los txiav txim siab lwm yam kab mob xws li qog lossis kab mob tiv thaiv kab mob, vim tias kev kho mob thiab kev kwv yees yuav txawv heev.
Feline eosinophilic granuloma complex kho mob
Qhov tseem ceeb tshaj plaws yog txhawm rau txheeb xyuas thiab tshem tawm qhov ua rau hypersensitivity lossis ua xua. Kev kho flea thiab tshem tawm cov zaub mov yuav tsum tau siv txhawm rau txhawm rau txhawm rau nrhiav zaub mov tsis haum. Txawm li cas los xij, qhov tom kawg yog txheej txheem ntev dua thiab nyuaj, yog li cov kev raug mob no feem ntau pib nrog cov kev kho mob hauv qab no:
- Glucocorticoids txo cov eosinophils thiab txhim kho qhov txhab. Lawv raug suav hais tias yog kev kho mob ntawm kev xaiv rau peb hom feline eosinophilic granuloma complex. Prednisolone 2-4 mg / kg / hnub tuaj yeem siv qhov ncauj thawj zaug, tapering mus rau 2 mg / kg txhua 48 teev kom txog rau thaum cov kab mob daws. Cov koob tshuaj ntawm 4 mus rau 5 mg / kg ntawm methylprednilsolone acetate subcutaneously lossis intramuscularly txhua 2 lub lis piam, nrog rau qhov siab tshaj plaws ntawm 3 daim ntawv thov, lossis dexamethasone ntawm koob tshuaj 0.1-0.2 mg / kg txhua 24 teev kuj tuaj yeem siv tau thaum pib thiab 0.05-0.1 mg. / kg txhua 72 teev rau kev saib xyuas qhov ncauj lossis ntxiv rau zaub mov. Yog tias cov tshuaj corticosteroids raug tshem tawm ua ntej qhov mob tau kho tag nrho, lawv yuav rov tshwm sim dua.
- Immunosuppressors immunomodulate lub cev tiv thaiv kab mob los ntawm kev txhaj tshuaj tiv thaiv kab mob. Cyclophosphamide tuaj yeem siv tau ntawm koob tshuaj 1 mg / kg ntawm qhov ncauj, 4 koob tshuaj txhua lub lis piam mus txog 4-6 lub lis piam thiab cov lus teb hauv kev txo cov kab mob yuav siv sijhawm li 1-4 lub lis piam. Cyclosporine kuj nquag siv los txo eosinophils nrog koob tshuaj 7 mg / kg txhua 24 teev rau 4 lub lis piam thiab, yog tias pom cov lus teb zoo, nws tuaj yeem txo qis txhua hnub thiab tom qab ntawd ob zaug hauv ib lub lis piam. Chlorambucil yog cov tshuaj ntawm kev xaiv thaum miv yog refractory rau glucocorticoids, thiab tuaj yeem ua ke nrog cov no ntawm koob tshuaj 0.1-0.2 mg / kg / hnub lossis txhua 2 hnub txog 4-8 lub lis piam, tab sis ib zaug cov lus teb zoo tau txiav txim siab hauv Cov kab mob, cov koob tshuaj ntawm glucocorticoids yuav tsum raug txo ua ntej, ua raws li cov tshuaj chlorambucil, tsuav lawv tseem rov qab mus. Dab tsi yog nrhiav nrog cov kev kho mob no yog nrhiav cov koob tshuaj qis tshaj plaws uas tso cai rau kev tshem tawm qhov mob.
- Antihistamines thaum miv muaj atopy, hypersensitivity rau flea tom los yog idiopathic aetiology. Chlorphenamine maleate thiab hydroxyzine hydrochloride tuaj yeem siv tau 15 hnub sib law liag. Txawm li cas los xij, yog tias qhov ua rau tsis paub lossis cov txheej txheem mob ntev heev lossis tsis tuaj yeem tswj tau, corticosteroids yuav muaj txiaj ntsig zoo dua.
- Antibiotics xws li amoxicillin-clavulanic acid ntawm 12.5 mg/kg/txhua 12 teev los yog trimethoprim-sulfamethoxazole ntawm 30 mg/kg / txhua. 12 teev, tab sis qhov zoo tshaj plaws yog cov tshuaj tua kab mob txiav txim siab los ntawm cov tshuaj tua kab mob. Qhov tsawg kawg nkaus ntawm kev kho tshuaj tua kab mob yog ob lub lis piam, thiab nws kav ntev li 10 hnub tom qab kho. Lawv muaj txiaj ntsig tshwj xeeb tshaj yog rau cov kab mob hauv plab, vim lawv cov keeb kwm feem ntau cuam tshuam nrog cov kab mob.
- Fatty acids rau cov zaub mov ntxiv rau cov mob ntev li 4-6 lub lis piam. Lawv muaj txiaj ntsig zoo rau eosinophilic granuloma.
- Surgery, cryosurgery los yog hluav taws xob rau tej yam kev raug mob uas yuav tsum tau nws vim lawv mob heev, refractory los yog nyuaj, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob. indolent ulcer.
Ntshav, biochemical, thiab urinalysis nrog kab lis kev cai yog xav tau nyob rau hauv miv kho nrog glucocorticoids los saib xyuas cov pob txha pob txha thiab saib xyuas cov teeb meem xws li kev loj hlob ntawm cov kab mob raum, kab mob sab sauv los yog ntshav qab zib.
Koj yuav tsum tsis txhob muab tshuaj rau koj tus miv vim tias, raws li koj tau pom, nws yog ib qho tseem ceeb rau kev kuaj mob los tsim kho.
Miv nrog eosinophilic granuloma complex feem ntau muaj cov tsos mob zoo nrog kev kho mob thiab tshuaj xyuas kom tsim nyog, nrog rau tus nqi siab dua ntawm cov kab mob miv uas refractory rau glucocorticoids, xav tau kev kho mob hnyav dua. Yog tias qhov tshwm sim tuaj yeem txiav txim siab thiab zam tau, cov kab mob yuav tsum ploj mus ib txhis.
Yog li no, yog muaj tej kab mob dermatological lesion uas peb tau hais rau hauv peb cov miv (rwj ntawm daim di ncauj sab sauv, qhov ncauj qhov ncauj, cov quav hniav ntawm qhov chaw ventral los yog qhov txhab ntawm tus ncej puab…), txawm lawv khaus los tsis yog, mus ntsib kws kho tsiaj yog qhov tseem ceeb, thiaj li nrhiav tau qhov teeb meem no rau lub sij hawm thiab kho tau.
