Feline infectious peritonitis is one of the cov kab mob loj tshaj plaws uas cuam tshuam rau felines, vim, ntawm lwm yam ua rau, rau qhov mob loj heev. muaj thiab raws li qhov tshwm sim ntawm qhov tsis muaj nyob, txog niaj hnub no, ntawm kev kho mob zoo tiag tiag.
Nws muaj ntau dua rau cov miv me uas muaj hnub nyoog qis dua ob xyoos thiab hauv cov miv uas muaj hnub nyoog tshaj 12 xyoos, nrog rau cov miv nyob hauv zej zog ntau dua. Tus kab mob no tshwm sim thaum tus feline enteric coronavirus mutates, thiab nws yog los ntawm lub sijhawm no ntawm qhov ntawd, nyob ntawm seb lub cev tiv thaiv kab mob ntawm tus feline, qhov hnyav qhuav lossis ntub daim ntawv ntawm tus kab mob yuav tsim. Hauv tsab xov xwm no ntawm peb lub xaib peb yuav qhia qhov tob hauv txhua yam koj yuav tsum paub txog Feline Infectious Peritonitis (FIP), kab mob ntawm kev txhawj xeeb rau cov miv thiab lwm yam mob siab rau felines.
feline infectious peritonitis yog dab tsi?
Feline infectious peritonitis (FIP) is a Feem ntau cov neeg tuag, kis kab mob uas cuam tshuam rau cov tsiaj qus thiab cov miv hauv tsev. Nws yog tus txheej txheem ntawm tus kab mob viral thiab kev faib thoob ntiaj teb uas muaj cov tshuaj tiv thaiv kab mob loj.
Tus kab mob no ntau dua nyob rau hauv kittens uas muaj hnub nyoog qis dua 2 xyoos thiab tshaj 12 xyoos hnub nyoog, tshwj xeeb tshaj yog cov neeg dawb huv ntawm cov liaj teb lossis cov neeg nyob hauv cov zej zog, vim muaj kev kis tus kab mob ntau dua uas ua rau nws.
Tus kab mob no, txawm tias nws puas tau ua tus kab mob peritonitis, cuam tshuam rau txoj hnyuvhauv miv.
Tus kab mob dab tsi ua rau FIP hauv miv?
The feline coronavirus (CoVF) is the agent that can lead to the development of FIP. Nws yog ib lub hnab RNA tus kab mob ntawm tsev neeg Coronaviridae thiab Alphacoronavirus genus. Nws kwv yees tias txog li 90% ntawm cov miv nyob hauv cov zej zog thiab txog li 50% ntawm cov neeg nyob ib leeg yog seropositive rau FCoV. Tus kab mob no nkag mus rau hauv qhov ncauj thiab mus rau lub plab hnyuv hlwb (enterocytes), qhov uas nws multiplies ua rau mob raws plab los ntawm lawv kho. Kev tso tus kab mob no pib ob lossis peb hnub tom qab kis kab mob thiab tuaj yeem nyob ntev, txawm tias lub neej ntawm tus miv.
Txawm li cas los xij, hauv tsawg dua 20% ntawm cov miv seropositive tus kab mob mutates, ua rau nws muaj peev xwm kis tau cov kab mob tiv thaiv kab mob hu ua macrophages thiab yog li kis thoob plaws hauv lub cev, ua rau muaj tus kab mob FIP. Nyob rau hauv txoj kev loj hlob ntawm tus kab mob no, lub xeev ntawm tus miv lub cellular tiv thaiv kab mob yog qhov tseem ceeb, yog li ntawd:
- Yog tias lub cev tiv thaiv kab mob hauv lub cev muaj zog, tus kab mob tsis tshwm sim.
- Yog hais tias lub cev tiv thaiv kab mob ntawm tes raug txwv ib nrab, qhuav FIP.
- Yog tias lub cev tiv thaiv kab mob hauv lub cev raug txwv hnyav, Wet FIP..
feline infectious peritonitis kis tau li cas?
Los ntawm kev cuam tshuam rau lub plab zom mov, FIP feem ntau kis tsis tau los ntawm cov quavlos yog ib yam khoom kis los ntawm tib yam, tshwj xeeb tshaj yog cov sandboxes uas nws tuaj yeem ua haujlwm tau ntev txog xya lub lis piam.
Ntawm qhov tod tes, tus kab mob tuaj yeem kis ncaj qha los ntawm cov qaub ncaug thiab txawm tias kis tus kab mob transplacental tau piav qhia. Raws li peb hais, nws yog ib tug kab mob sib kis heev, yog li nws yog ib qho tseem ceeb kom cais tus miv kis tus kab mob los ntawm tus so yog tias ob peb miv nyob hauv tsev.
Puas yog feline infectious peritonitis kis tau rau tib neeg?
No, FIP kis tsis tau rau tib neeg. Nov yog tus kab mob no tsuas kis tau ntawm cov miv xwb, yog li ntawd tib neeg thiaj ntes tsis tau.
Feline Infectious Peritonitis Cov tsos mob
Cov tsos mob tshwm sim rau cov ntawv qhuav thiab ntub dej ntawm FIP yog cov tsos mob tsis tshwj xeeb: kub taub hau, kev nyuaj siab, hloov pauv anorexia, pallor ntawm mucous membranes los yog jaundice, hnyav poob thiab stunted loj hlob nyob rau hauv kittens.
Symptoms of dry FIP
Hauv daim ntawv qhuav ntawm FIP, muaj hom IV hypersensitivity uas tshwm sim los ntawm kev tsim cov pyogranulomatous infiltrates feem ntau nyob ib ncig ntawm cov hlab ntsha. Cov piogranulomas yuav tsim cov tsos mob txawv txav nyob ntawm lub cev uas lawv cuam tshuam:
- Hauv lub raum, lawv yuav tsim cov tsos mob ntawm lub raum.
- Nyob hauv siab, siab tsis ua hauj lwm.
- Nyob rau hauv lub ntsws los yog pleura, dyspnea thiab ua pa pa.
- Nyob hauv txoj hnyuv, hnyuv, cecum thiab ileocolic lymph nodes, nws yuav ua rau digestive tsos mob xws li ntuav lossis raws plab.
- Nyob rau hauv lub hlwb, cov tsos mob xws li qaug dab peg, hloov lub hlwb, hloov tus cwj pwm, cranial paj deficits, vestibular cim, hyperesthesia, ataxia, tetraparesis, thiab txawv txav postural tshua.
Cov tsos mob ntawm daim tawv nqaij kuj tseem tshwm sim, xws li tsis khaus erythematous papules ntawm lub pob tw thiab caj dab, subcutaneous edema, daim tawv nqaij fragility syndrome thiab nodules ntawm caj dab thiab forelimbs. Generalized synovitis tuaj yeem pom hauv cov pob qij txha, thiab qhov muag kuj tuaj yeem cuam tshuam nrog anterior uveitis, chorioretinitis, hyphema, hypopyon, keratin precipitates, thiab retinal detachment.
Lwm cov tsos mob uas yuav pom nyob rau hauv miv nrog FIP qhuav yog rho menyuam thiab metritis.
Symptoms of wet FIP
Nyob rau hauv ntub dej FIP muaj infiltration ntawm tus kab mob macrophages mus rau hauv cov ntaub so ntswg nyob ib ncig ntawm cov hlab ntsha thiab tom qab deposition ntawm lub cev tiv thaiv complexes nyob rau hauv cov hlab ntsha nrog rau ntxiv ua kom ua rau vasculitis, kev puas tsuaj rau vascular endothelium thiab to. cov ntshav thiab albumin proteins los ntawm capillaries. Nws yog daim ntawv mob hnyav tshaj plaws thiab muaj qhov tshwm sim phem tshaj plaws ntawm tus kab mob.
Nws yog tus yam ntxwv los ntawm kev tsim ntawm painless effusions muaj li ntawm ib tug yellowish straw-xim kua nrog albumen proteins nyob rau hauv:
- Khaus dej hauv plab plab (ascites) hauv cov miv feem coob.
- Pleura (pleuritis) txog li 40% ntawm cov miv.
Chin, scrotal edema thiab pericardial effusion ua rau lub plawv tsis ua hauj lwm kuj tshwm sim.
Cov tsos mob ntawm jaundice ntau zaus dua li hauv daim ntawv qhuav vim lub siab tsis ua hauj lwm los yog kev tiv thaiv kab mob hemolytic anemia thiab cuam tshuam ntawm cov qog necrosis ntau alpha uas cuam tshuam nrog bilirubin thauj mus rau hauv thiab tawm. ntawm daim siab hlwb. Neurological thiab ocular cim ntawm daim ntawv qhuav kuj tshwm sim.
Diagnosis of Feline Infectious Peritonitis
Qhov tsawg kawg nkaus ua rau tus miv uas muaj cov tsos mob ntawm FIP yog ib qho , qhov twg leukocytosis nrog lymphopenia thiab neutropenia tuaj yeem pom (Cov qe ntshav dawb nce ntxiv tab sis txo cov lymphocytes thiab neutrophils), nrog rau cov ntshav tsis muaj ntshav qab zib hom 1 ntawm cov txheej txheem mob ntev. Txawm li cas los xij, qhov no tsis yog tshwj xeeb thiab tuaj yeem haum nrog ntau yam kab mob uas miv tuaj yeem raug kev txom nyem los ntawm.
Serological testing for feline coronavirus is not use as many cats are positive and tsis muaj tus kab mob. Qhov tshwm sim ntawm tus miv nthuav qhia FIP nce nrog:
- Ib albumin/globulin ratio tsawg dua 0.4.
- Ib qhov zoo Riv alta test, txawm li cas los xij septic exudates thiab lymphomas kuj tuaj yeem ua tau zoo. Txawm li cas los xij, nws yog ib qho kev sim zoo los txiav tawm tus kab mob, nrog rau 97% kev ntseeg tau.
Yog tias muaj cov tsos mob ntawm lub paj hlwb, yuav tsum tau coj mus kuaj cov kua cerebrospinal, qhov twg cov protein ntau (50-350 mg/dl) thiab cov hlwb (100-100,000 nucleated cells/ml) yuav pom..
Kom kuaj mob feline infectious peritonitis, ua raws li hauv qab no:
- Diagnosis of ntub FIP: yuav tsum tau coj ib tug qauv ntawm cov kua los ntawm cov ascites los yog pleurisy, uas yuav tsum khov, yellowish-reddish., tsis muaj kab mob, nrog ntau cov proteins (ntau dua 35 mg / ml) thiab ob peb lub hlwb (tsawg dua 5,000 / ml). Qhov kev ntsuam xyuas zoo tshaj plaws rau kev kuaj xyuas daim ntawv ntub dej yog immunofluorescence txhawm rau saib tus kab mob hauv cov kua dej effusion.
- Dry FIP diagnosis: Feem ntau qhov kev kuaj mob yog tsim thaum tus miv tau hmoov tsis tau tuag, coj cov qauv ntawm nws lub cev. Hauv cov tsiaj muaj sia, yuav tsum tau ua qhov kev kuaj mob txhawm rau txhawm rau kuaj ntshav. Nyob rau hauv ob qho tib si, qhov kev kuaj pom tseeb tshaj plaws yog tau los ntawm cov txheej txheem immunohistochemical nrog tus mob coronavirus antigen staining los ntawm cov qauv no.
Feline infectious peritonitis kho mob
Puas muaj kev kho mob feline kis kab mob peritonitis? Hmoov tsis zoo, niaj hnub no FIP tseem muaj tus kab mob uas muaj qhov tsis zoo heev uas kho tsis tau, txawm hais tias tau muaj cov kev tshem tawm, tshwj xeeb tshaj yog ntawm daim ntawv qhuav.
Kev kho mob yog ua raws li kev kho mob
- noj zaub mov muaj protein ntau.
- Kev tswj hwm ntawm cov enzymes proteolytic.
- Vitamin complexes (A, B, C, E).
- Pleural effusion kua yog tias muaj peev xwm ua pa raug cuam tshuam.
- Txhaj tshuaj dexamethasone rau hauv lub plab los yog thoracic kab noj hniav (1 mg / kg txhua 24 teev kom txog rau thaum lub effusion tsis tshwm sim, mus txog rau xya hnub; yog hais tias muaj effusion nyob rau hauv ob kab noj hniav, koob tshuaj ib kab noj hniav. yuav tsum muab faib).
- Cov tshuaj tiv thaiv kab mob.
- Prednisolone thiab cyclophosphamide kom txo tau qhov hnyav ntawm lub cev tiv thaiv kab mob thiab vasculitis los ntawm kev nyuaj siab lub cev tiv thaiv kab mob.
- Recombinant feline interferon omega (FelFN-w) as an enhancer cellular immune response.
Nyob rau xyoo tas los no, kev cia siab ntawm kev nrhiav kev kho tus kab mob no tau nce ntxiv, vim muaj ntau yam kev tshawb fawb tau soj ntsuam kev ua tau zoo thiab kev nyab xeeb ntawm ntau cov khoom xyaw nquag, feem ntau ntawm lawv hauv cov hlwb, tab sis lwm tus twb tau ua tiav lawm. raug sim rau miv. Ntawm lawv, ob cov tshuaj tau qhia txog kev ua tau zoo thiab kev nyab xeeb hauv kev kho mob ntawm FIP: 3C protease inhibitor GC376 thiab nucleoside analog GS-441524. Txawm li cas los xij, tseem xav tau kev tshawb fawb ntxiv ua ntej lawv yuav muaj muag hauv hom no.
Life expectancy of a miv with FIP
PIB kho siab heev. Hmoov tsis zoo, cov miv feem ntau tuag nyob rau hauv hli ntawm kev kuaj mob. Tsis tas li ntawd, yog lawv tsim daim ntawv ntub dej, feem ntau ntawm lawv feem ntau raug tua tsis pub dhau 10 hnub txhawm rau kom tsis txhob ua rau tus tsiaj muaj kev txom nyem ntev.
Feline infectious peritonitis yog ib yam kab mob uas tua ib ncig ntawm 0.3-1.4% ntawm cov miv hauv ntiaj teb, yog tus kab mob tseem ceeb ua rau cov miv hluas tuag, thiab yog ib qho kev hem thawj ntxiv rau cov miv tsiaj qus.
Yog tias kuaj tau tus kab mob no, kev saib xyuas tus miv nrog FIP yog raws li tau piav qhia hauv nqe lus dhau los ntawm kev kho cov tsos mob, yog li nws yuav tsum tsim kom muaj kev noj zaub mov kom txaus thiab ua raws li cov lus qhia tsim los ntawm kws kho tsiaj..
Yuav ua li cas tiv thaiv FIP hauv miv?
Vim tias feline kis kab mob peritonitis yog kev hloov pauv ntawm tus kabmob feline, nws yog ib qho tseem ceeb uas yuav tau sim tiv thaiv qhov kawg. Yog li, tsis muaj tshuaj tiv thaiv kab mob feline kis kab mob peritonitis, tab sis muaj tshuaj tiv thaiv kab mob felineTxawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tsum tau taw qhia tias nws nyuaj heev los tswj qhov no. kab mob los ntawm kev txhaj tshuaj, txij li thaum nws tau muab thaum cov miv muaj hnub nyoog ntawm 16 txog 19 lub lis piam, ib lub hnub nyoog uas muaj ntau tus miv twb tau kis tus kab mob no.
Dab tsi, peb hais txog qhov tseem ceeb ntawm kev cais tus miv kis tus kab mob FIP los ntawm lwm tus miv yog tias muaj ntau tus miv nyob hauv tib tsev.
