Cov kab mob plob tsis so tswj lossis IBD hauv cov dev muaj cov txheej txheem mob ntev uas tuaj yeem cuam tshuam rau ntau ntu ntawm cov hnyuv, thiab nws tshwm sim. vim muaj cov kab mob inflammatory hauv lub plab hnyuv mucosa (lymphocytes, plasma hlwb, eosinophils thiab macrophages). Vim li no, ntau hom IBD tuaj yeem tshwm sim, nyob ntawm seb hom kev tswj hwm ntawm tes.
Nyob rau hauv txhua yam, cov kev kuaj mob tshwm sim yog mob raws plab Kev kuaj pom tseeb yog tiav nrog histopathology thiab kev kho mob yuav tsum muaj nyob rau hauv kev noj haus thiab pharmacological kev kho mob. Yog tias koj xav paub ntxiv, nyeem cov kab lus no hauv peb lub xaib kom paub txog cov kab mob digestive uas tuaj yeem cuam tshuam rau peb cov dev, nws cov tsos mob, kuaj mob thiab kho.
Dab tsi yog kab mob plab plob tsis so tswj hauv dev?
Canine inflammatory bowel disease los yog IBD (Inflammatory bowel Disease), muaj ib tug chronic enteropathy tus cwj pwm los ntawm enteritis lossis o ntawm txoj hnyuv los ntawm infiltrate ntawm inflammatory cells (lymphocytes, plasma hlwb, eosinophils, macrophages los yog ua ke ntawm no) nyob rau hauv lub mucosa ntawm tus dev txoj hnyuv.
Ua rau tus kab mob plob tsis so tswj hauv dev
Lub hauv paus chiv keeb tsis paub meej, tab sis muaj ib qho exaggerated teb rau ib tug series ntawm antigens, xws li:
- kab mob plab hnyuv microflora.
- noj zaub mov tsis haum.
- Cov khoom ntawm lub plab zom mov nws tus kheej hauv kev sib cuag nrog cov mucosa ntawm txoj hnyuv.
Cov lus teb tsis txaus ntseeg ntawm lub cev tiv thaiv kab mob hauv zos ntawm tus dev txoj hnyuv tuaj yeem tshwm sim los ntawm cov plab hnyuv permeability, ua rau muaj kev cuam tshuam ntau ntxiv. antigens uas twb muaj lawm. Rau nws ib feem, cov inflammatory infiltrate uas tsim ua rau ib tug mob nyob rau hauv lub mucosa uas ua rau kom ntau dua nqus ntawm antigens thiab proinflammatory tshuaj uas ua rau cov txheej txheem mob.
Cov plab hnyuv microbiota tuaj yeem raug kev hloov pauv vim muaj kev hloov pauv hauv kev nqus thiab plab hnyuv peristalsis tshwm sim los ntawm tus kab mob.
Types of inflammatory bowel disease in dogs
Nyob ntawm seb hom cell twg predominates nyob rau hauv inflammatory infiltrate ntawm lamina propria ntawm txoj hnyuv mucosal txheej, cov nram qab no hom ntawm enteritis yog txawv:
- Lymphoplasmacytic enteritis: infiltrate nyob rau hauv txoj hnyuv lamina propria ntawm lymphocytes thiab plasma hlwb. Hom IBD no feem ntau kuaj tau hauv cov dev. Basenji, German Shepherd thiab Shar Pei dev yug tau ntau dua.
- Eosinophilic enteritis: infiltrate ntawm eosinophils hauv plab hnyuv mucosa. Nws muaj ntau dua hauv rottweilers.
- Granulomatous enteritis: infiltrate of granulomatous formations of epithelial cells. Cov hom cell loj tshaj plaws yog macrophages.
Qee zaum cov nyuv tuaj yeem cuam tshuam, sib txawv plaub hom kab mob colitis:
- Lymphoplasmacytic colitis: infiltrate of lymphocytes and plasma cells in the mucosa ntawm txoj hnyuv.
- Eosinophilic colitis: infiltrate ntawm eosinophils hauv mucosa ntawm txoj hnyuv.
- Granulomatous colitis: infiltrate of granulomatous formations of epithelial cells in the nylon.
- Histiocytic-ulcerative colitis: tshwj xeeb tshaj yog nyob rau hauv boxers, nws yog yus muaj los ntawm ib tug txo caliber ntawm lub lumen ntawm txoj hnyuv loj, nrog rau ib tug txo nyob rau hauv lub caliber. mucosa tuab heev, tsis xwm yeem, eroded, congested thiab nrog cov cheeb tsam ntawm active los ntshav.
plab hnyuv lymphagiectasia, tus yam ntxwv los ntawm edema thiab dilation ntawm cov hlab ntsha lymphatic, tuaj yeem poob rau hauv IBD complex vim nws nquag muaj ntau. Cov txheej txheem no tshwm sim nrog cov kab mob no.
Symptoms of IBD in Dogs
Cov dev uas muaj kab mob plab hnyuv muaj feem ntau cov tsos mob ntawm mob raws plab, tsis zoo li miv nrog IBD, uas qhia ntau ntuav thiab hnyav. poob. Ntxiv nrog rau qhov mob raws plab, dev nrog enteritis lossis inflammatory colitis yuav tshwm sim:
- Nyob.
- Pab kev hloov pauv.
- Nutrient malabsorption.
- Nyob tsis taus.
- Vim plab plab.
- Cov quav quav hauv plab enteritis.
- Cov quav ntshav los yog mucous hauv plab colitis.
- Nkauj kho siab.
- Flatulence.
- mob plab.
- Anemia.
- Ascites lossis peripheral edema yog tias protein-poob enteropathy tau tsim.
Diagnosis of bowel disease in dogs
Thawj qhov hauv kev kuaj mob IBD yog txiav txim siab tawm lwm qhov kev kuaj mob sib txawv uas yuav ua rau muaj cov tsos mob zoo sib xws ua ntej ua plab hnyuv biopsy rau koj cov tshuaj anatomopathological txoj kev kawm, uas yog qhov kev kuaj mob ntawm tus kab mob no.
Ua li no, ntxiv nrog rau keeb kwm kev kho mob zoo thiab kev kuaj lub cev, kev sim hauv qab no yuav tsum tau ua:
- Bone scan.
- Ultrasound.
- Stool culture.
Yog tias cov kab mob no raug txiav tawm, qhov kev kuaj mob yuav tsum raug lees paub los ntawm kev noj tshuaj biopsies. Cov biopsies no muaj xws li tau txais ib feem ntawm tus dev txoj hnyuv rau kev kawm ntxiv. Biopsies yuav tsum tau txais los ntawm endoscopy los yog laparotomy (kev tshawb nrhiav kev phais). Nyob ntawm seb hom cell (s) uas tseem ceeb tshaj plaws ntawm histopathology, hom kab mob plab hnyuv uas tus dev raug mob yuav raug kuaj xyuas.
Canine IBD Treatment
Kev kho mob IBD yeej tsis kho, tab sis nws muaj peev xwm tswj cov tsos mob ntawm tus tsiaj, txawm tias qhov mob ua rau ua tsaug.
Kev kho mob yuav nyob ntawm qhov mob plab hnyuv loj thiab muaj hypocobalamineemia (tsawg vitamin B12), yog li sib txawv rau plaub qhov ntsuas ntawm kev kho mob nrog kev kho mob tshwj xeeb raws li cov txheej txheem:
Kev kho mob ntawm canine IBD nrog qis kev kho mob Performance index
Histopathology qhia tias tsis muaj qhov txawv txav, ua rau IBD nug. Tsis tas li ntawd, qhov concentration ntawm albumin yog qhov qub. Nyob rau hauv cov ntaub ntawv no, kev kho empirical yuav tsum muaj xws li:
- Fenbendazol (50 mg/kg rau 5 hnub): kom tswj tau Giardia thiab lwm yam kab mob sab hauv.
- Hypoallergenic diet nrog hydrolyzed los yog cov protein tshiab: yog tias cov tsos mob tshwm sim, nws qhia tau hais tias kev noj zaub mov noj enteropathy lossis zaub mov tsis txaus, tsis yog IBD..
- Antibiotics: xws li tylosin lossis metronidazole. Yog tias muaj lus teb zoo, nws yog enteropathy uas teb rau cov tshuaj tua kab mob.
Kev kho mob ntawm canine IBD nrog kev kho mob me me-nruab nrab qhov ntsuas ntsuas
Muaj qhov txawv txav ntawm IBD ntawm histopathology, tab sis cov albumin concentration ntau dua 2 g / L. Kev kho mob hauv qhov no yuav yog:
- Fenbendazol (50 mg/kg rau 5 hnub): kom tswj tau Giardia thiab lwm yam kab mob sab hauv.
- Hypoallergenic diet nrog hydrolyzed los yog tshiab protein: tsawg kawg yog ob lub lis piam.
- Antibiotics: xws li tylosin lossis metronidazole rau ob lub lis piam. Yog muaj lus teb zoo, rau ib hlis.
- Glucocorticoids ntawm cov tshuaj tiv thaiv kab mob: prednisone (2 mg / kg / 24 h) rau 2-4 lub lis piam kom txog thaum cov tsos mob zoo, tom qab ntawd txo qis. koob tshuaj maj mam mus rau qhov tsawg kawg nkaus.
Yog cov lus teb tsis txaus, ntxiv lwm cov tshuaj tiv thaiv kab mob, xws li:
- Azathioprine (2 mg/kg/24 h rau 5 hnub thiab ces 2 mg/kg txhua 2 hnub).
- Cyclosporine (5 mg/kg/24 h)
Kev kho mob ntawm canine IBD nrog rau qhov nruab nrab-qhov hnyav qhov chaw kho mob index
Cov kev hloov hauv histology yog qhov siab heev thiab cov albumin concentration tsawg dua 2 g / l. Kev kho mob hnyav IBD yog raws li hauv qab no:
- Fenbendazol (50 mg/kg rau 5 hnub): kom tswj tau Giardia thiab lwm yam kab mob sab hauv.
- Hypoallergenic diet nrog hydrolyzed protein.
- Antibiotics: xws li tylosin lossis metronidazole rau ob lub lis piam. Yog muaj lus teb zoo, rau ib hlis.
- Glucocorticoids ntawm koob tshuaj tiv thaiv kab mob: yog tias tsis zoo, lwm yam tshuaj tiv thaiv kab mob (azathioprine (2 mg / kg / 24 h rau 5 hnub thiab tom qab ntawd 2. mg/kg txhua 2 hnub) los yog cyclosporine (5 mg/kg/24 h). Yog tias nws tsis zoo los yog xav tias kev nqus ntawm cov hnyuv tsis txaus, txhaj tshuaj corticosteroids tuaj yeem sim.
- Antithrombotics: Yog tias lawv tau tsim cov protein-poob enteropathy, ntxiv cov tshuaj tua kab mob xws li tshuaj aspirin lossis clopidrogel yuav tsum tau txiav txim siab, vim tias cov dev no. muaj kev pheej hmoo siab ntawm kev tsim cov kab mob thromboembolic vim qhov poob ntawm antithrombin ntawm txoj hnyuv.
- Cobalamin: muab cobalamin (vitamin B12) ib hlis ib zaug rau ib hlis, thiab tom qab ntawd ib hlis ib zaug rau 3 lub hlis. Tom qab ntawd, rov ntsuas qhov ntsuas seb puas tsim nyog ntxiv ntxiv lossis tsis.
Hauv cov dev uas muaj kab mob ulcerative-histiocytic colitis, kev siv cov enrofloxacin rau lub sijhawm ntev yog kev kho mob, vim tias tus kab mob no cuam tshuam nrog cov kab mob Escherichia coli uas nkag mus tob tob hauv cov hnyuv loj.
