Allopurinol yog ib hom tshuaj siv hauv tib neeg cov tshuaj los txo cov qib ntawm uric acid hauv ntshav thiab zis vim tias nws inhibits ib qho enzyme koom nrog hauv nws tsim. Hauv cov tshuaj kho tsiaj, qhov tshwj xeeb no hauv dev, nws yog ib qho tshuaj uas siv nrog antimonials lossis miltefosine rau kev kho mob leishmaniosis.
Yog koj xav paub ntau ntxiv txog cov tshuaj no, txuas ntxiv nyeem tsab xov xwm no ntawm peb lub vev xaib uas peb tham txog allopurinol rau dev, nws siv, pom zoo npaum li cas thiab cov kev phiv tshwm sim.
Allopurinol yog dab tsi thiab nws siv rau dab tsi?
Allopurinol yog ib qho enzyme inhibitor uas, tshwj xeeb tshaj yog, inhibits lub enzyme uas metabolizes hloov dua siab tshiab ntawm xanthine rau uric acid. Nws tsis yog siv ib leeg xwb, tab sis ua raws li ib tug adjuvant rau lub ntsiab leishmanicidal tshuaj, antimonial los yog miltefosine, sim kom tshem tawm tag nrho cov cab los ntawm tag nrho cov ntaub so ntswg. Nyob rau hauv txoj kev no, kev siv allopurinol hauv dev yog txo rau ib qho: kev kho mob leishmania.
Cov tshuaj no yog muab los ntawm qhov ncauj thiab nws txoj kev kho mob tuaj yeem kav li 6 lub hlis mus rau ib xyoos Tseem muaj cov xwm txheej uas nws tau tsim muaj. kev kho mob ntev dua. Txawm li cas los xij, kev tshuaj xyuas thiab kev soj ntsuam ntawm rooj plaub yuav tsum tau ua thaum kho tau tsim, ua rau lub siab tias qhov zaus ntawm kev tshuaj xyuas yuav raug tsim los ntawm kws kho tsiaj, vim nws yuav tsum yog tus kheej nyob ntawm qhov hnyav ntawm txhua kis.
Allopurinol therapy yuav tsum yog tus kheej rau tus neeg mob. Ib qho piv txwv zoo yuav yog miltefosine txhua hnub rau kwv yees li 1 lub hlis ua ke nrog allopurinol txhua hnub rau kwv yees li 8 lub hlis.
Allopurinol rau dev nrog leishmania
Raws li peb tau hais hauv nqe lus dhau los, allopurinol yog siv rau kev kho mob leishmania. Leishmaniasis yog ib tug kab mob kab mob parasitic tshwm sim los ntawm ib tug protozoan uas kis tau los ntawm ib tug tom ntawm ib tug vector: cov yoov tshaj cum sandfly. Nws yog ib qho zoonosis, nrog rau kev faib thoob ntiaj teb thiab loj heev, yog li ntxiv nrog rau kev tiv thaiv kev tiv thaiv uas siv los txo nws cov kev nthuav dav (cov tshuaj tiv thaiv, cov dab tshos thiab cov kav dej, cov tshuaj tiv thaiv kab mob) txhua tus yuav tsum tau kho cov dev uas muaj kab mob.
Cov dev mob yog cov uas pom cov tsos mob tshwm sim thiab tus kab mob leishmania tau lees paub los ntawm kev kuaj mob. Nws yog ib yam kab mob uas tsis yog tshwj xeeb, uas yog, nws tuaj yeem tshwm sim nrog ntau cov tsos mob, yog li keeb kwm zoo ntawm kev kis kab mob ntawm qhov chaw uas tus tsiaj nyob. tseem ceeb heev. dev thiab nws cov xwm txheej tiv thaiv nws. Qee yam ntawm cov cim no yog: crusty thiab ulcerative dermatoses, lameness, qhov ntswg los ntshav, qhov ntswg thiab ncoo hyperkeratosis, lethargy, thiab lwm yam. Tus kab mob tuaj yeem raug cais ua visceral leishmaniasis lossis cutaneous leishmaniasis.
Nws yog ib qho uas, ntxiv rau leishmania, tus aub raug kev txom nyem los ntawm lwm cov kab mob ntshav parasitic, vim nws txuas nrog rau qib ntawm kev tiv thaiv kab mob ntawm peb tus dev. Vim li no, leishmaniasis yuav tsum tau kho thaum tus dev nyob ruaj khov, uas yog, yog tias tus kab mob tau ua rau mob ntshav qab zib, lub raum tsis ua haujlwm, dermatitis, thiab lwm yam, cov mob no yuav tsum tau txhawb nqa ua ntej.
Miltefosine thiab antimonials yog cov tshuaj leishmanicidal (lawv tshem tawm cov kab mob cab) thiab lawv qhov kev ua tau nrawm dua thiab hnyav dua, thaum allopurinol yog leishmanistatic (slows down the multiplication of parasite). Vim li no, nws yog ib qho uas siv cov tshuaj no ua ke. Txawm li cas los xij, ntau thiab ntau tus kws kho tsiaj nyiam tshawb nrhiav lwm txoj hauv kev rau allopurinol vim yog cov teebmeem tsis zoo uas cov tshuaj no nthuav tawm rau cov neeg mob, thiab peb yuav pom hauv ntu hauv qab no..
koob tshuaj allopurinol hauv dev
koob tshuaj allopurinol rau cov dev tsim los kho cov kab mob leishmaniasis yog 10 mg rau ib kg ntawm qhov hnyav txhua 12 teev, uas yog, ob zaug ib hnub.
Cov tshuaj nthuav qhia uas muaj nyob rau hauv yog 100 mg thiab 300 mg ntsiav tshuaj ntawm allopurinol, yog li peb tus kws kho tsiaj yuav qhia peb tias pes tsawg ntsiav tshuaj peb yuav tsum tau tswj raws li qhov hnyav ntawm peb tus dev. Ib yam li ntawd, cia peb nco ntsoov tias nws yuav tsum yog tus kws tshaj lij uas txiav txim siab txog lub sijhawm ntawm kev kho mob, uas yuav tsum tsis txhob tuag tes tuag taw yam tsis tau pom zoo ua ntej.
Allopurinol Cov Kev Mob tshwm sim hauv dev
Muaj ob qhov kev mob tshwm sim tseem ceeb uas allopurinol tuaj yeem ua rau dev noj:
- Xanthinuria: thaum purines raug degraded los ntawm cov enzymes coj, xanthine yog tsim thiab qhov no, nyob rau hauv lem, hloov mus rau hauv acid uric. Allopurinol cuam tshuam nrog kev hloov pauv ntawm xanthine rau hauv uric acid, uas yuav tsum tau muab tshem tawm hauv cov zis, ua rau xanthine ntau dhau thiab nws cov tsub zuj zuj
- Urolithiasis: Tshaj xanthine crystals tuaj yeem tsim cov khoom sib xyaw nrog cov organic teeb meem thiab tsim uroliths (pob zeb). Cov uroliths no yog radiolucent, uas yog, lawv tsis pom nrog ib qho yooj yim x-ray thiab qhov sib txawv x-ray lossis ultrasound yuav tsum tau kuaj xyuas lawv.
Cov tsos mob tshwm sim tuaj yeem pom nrog cov kab mob no yog:
- dysuria (mob tso zis)
- hematuria (ntshav hauv zis)
- urinary incontinence
- urinary obstruction
- pab mob plab
Hnub no peb tuaj yeem nrhiav cov khoom noj dev uas tsim los rau kev kho mob leishmaniasis. Lawv yog cov yam ntxwv los ntawm lawv cov ntsiab lus purine tsawg, yog li tiv thaiv kev tsim ntawm xanthine crystals. Tsis tas li ntawd, lawv nthuav tawm cov tshuaj uas pab tiv thaiv pob qij txha, tawv nqaij thiab tiv thaiv kab mob. Yog xav paub ntxiv, tsis txhob nco peb tsab xov xwm ntawm Khoom noj rau dev nrog leishmaniasis.
Alternatives to Allopurinol for Dogs
Raws li peb tau hais hauv ntu dhau los, cov kev mob tshwm sim ntawm allopurinol tau ua rau ntau tus kws kho tsiaj xaiv los nrhiav lwm txoj hauv kev rau cov tshuaj no. Hauv qhov kev nkag siab no, kev tshawb fawb tsis ntev los no [1] lees paub tias ipromune, a nutraceutical based on nucleotides, muaj txiaj ntsig tiv thaiv kev nce qib ntawm leishmania thiab tsis tsim cov teebmeem uas tsis xav tau.
Cov kev hloov tshiab hauv kev kho mob leishmania coj peb mus rau kev siv cov tshuaj tshiab no uas tsis muaj kev phiv. Qhov tsis zoo yog tias nws yog tshuaj kim dua piv rau allopurinol.
