Ketoconazole yog ib qho tshuaj tua kab mob siv rau hauv miv kom tshem tawm cov tawv nqaij, kab mob thiab cov pob txha mycoses, ua tawm tsam cov kab mob xws li cov kab mob dermatophytes ua rau cov kab mob ringworm, cov poov xab xws li candida lossis malassezia thiab cov kab mob fungi xws li aspergillus lossis histoplasma.. Cov tshuaj no muaj cov nyhuv fungistatic thiab sporicidal vim tias nws rhuav tshem qhov sib npaug ntawm cov cell membrane ntawm cov fungus los ntawm kev khi rau ib qho enzyme uas tsim cov tshuaj sib npaug thiab txhawb kev ua haujlwm zoo ntawm cov cell membranes ntawm cov fungus, qhov tseem ceeb rau nws txoj sia nyob thiab kev loj hlob…
Ketoconazole yog dab tsi?
Ketoconazole yog ib tug broad-spectrum active ingredient los ntawm cov pab pawg neeg ntawm antifungals, uas yog, lub tshuaj npaj los kho fungi Hauv cov pob zeb yog ib tug fungistatic ntawm pawg azole, ib tug hluavtaws derivative ntawm imidazole thiab thawj qhov ncauj antifungal nrog ib tug dav spectrum.
Ketoconazole's mechanism of action tsis txawv ntawm lwm yam imidazole antifungals, yog li damages fungal cell membranes Tshwj xeeb, Cov khoom xyaw nquag no yog lub luag haujlwm., los ntawm kev khi nrog P-450 enzymes ntawm fungus cytochrome nrog zoo affinity, inhibit lub synthesis ntawm ergosterol, uas yog ib tug compound nyob rau hauv lub cell membranes ntawm fungus thiab ua kom tiav ib tug muaj nuj nqi zoo ib yam li cov cholesterol ntawm mammalian hlwb, uas yog., nws muaj peev xwm ntawm hloov cov permeability thiab fluidity ntawm daim nyias nyiasthiab tswj qee cov cellular proteins. Vim li no, lub cell membrane ntawm fungus tsis ua kom tiav nws lub luag haujlwm, ua qhov tsis zoo.
Kev nqus Ketoconazole hauv miv yog qhov ncauj sai heev ua lipophilic heev, tshwj xeeb tshaj yog tias noj nrog zaub mov. Ketoconazole khi rau albumin thiab lwm yam plasma proteins thiab nthuav tawm ntau qhov kev faib tawm, mus txog high concentrations hauv:
- Kidneys
- Lungs
- Pancreas
- Cov qog adrenal
Ketoconazole yog metabolized hauv daim siab thiab tshem tawm feem ntau hauv cov kua tsib thiab, tsawg dua, hauv cov zis los ntawm lub raum.
Ketoconazole yog dab tsi siv rau miv?
Ketoconazole hauv miv yog siv ua broad-spectrum fungistatic thiab sporocidal antimycotic, vim nws txoj kev ua haujlwm zoo rau kev kho cov kab mob fungi. los ntawm qhov chaw sib txawv thiab hom. Tshwj xeeb, Ketoconazole's antifungal spectrum tuaj yeem tiv thaiv cov kab mob hauv qab no thiab cov poov xab:
- Aspergillus
- Blastomyces
- Cryptococcus
- Histoplasma
- Candida
- Microsporum
- Trichophyton spp.
- Malassezia
- Dermatiaceous Fungi
- Pythium
- Pseudomycetomas
Ntxiv rau, Ketoconazole kuj muaj antiglucocorticoid thiab antiandrogenic teebmeem, inhibiting hloov cov roj cholesterol mus rau steroid hormones xws li cortisol thiab testosterone, thiab. los ntawm inhibition ntawm cytochrome P450 enzymes uas tseem koom nrog hauv nws cov synthesis.
Ketoconazole ntau npaum rau miv
Thaum peb tham txog Ketoconazole rau miv, peb yuav tsum coj mus rau hauv tus account tias peb tuaj yeem ua tau los ntawm qhov pom ntawm cov tshuaj los ntawm cov tshuaj pleev ib ce lossis, yog tias tsis yog, dhau ntawm qhov ncauj. Yog li, koob tshuaj ketoconazole rau miv yuav nyob ntawm:
- Daim ntawv qhia tshuaj.
- Koj qhov kev xav ntawm cov khoom.
Tshuaj Ketoconazole Dosage for Cats
Ketoconazole hauv miv tuaj yeem ua tau siv tshuaj pleev ib ce rau cov mob me me lossis nruab nrab ntawm cov tawv nqaij. Feem ntau nyob rau hauv tib lub qab zib peb kuj tuaj yeem pom lwm cov khoom xws li omega 6 fatty acids rau lawv cov kev tiv thaiv kab mob, ua rau miv lub cev tiv thaiv kab mob mus rau thaj tsam thiab ua rau cov kab mob cuam tshuam thiab zinc oxide kom rov tsim cov epidermis. Feem ntau yog Num Rau Tus Neeg Mob Ntaub Ntawv Daim Ntawv Qhia Thiab Tus Kws Kho Mob thiab daim ntawv thov yuav tsum raug tso tseg ib lub lim tiam tom qab tshem tawm qhov mob. Tseem muaj cov kev kho mob ntxiv xws li tshuaj zawv plaub hau ketoconazole.
Ketoconazole Oral Dosage for Cats
Lwm txoj kev siv Ketoconazole yog qhov ncauj, ua ke nrog zaub mov thiab hauv daim ntawv ntsiav tshuaj. Qhov koob tshuaj Ketoconazole hauv miv Cov pob txha theem kev kho mob ntev dua, yuav tsum tauncua sij hawm 2 lossis 3 lub hlis thiab txhua qhov kev kho mob yuav tsum tau txuas ntxiv mus rau lwm lub lis piam tom qab tshem tawm cov tsos mob tshwm sim. ntawm tus kab mob.
Ketoconazole Cov Kev Mob tshwm sim rau miv
Hauv miv, cov kev mob tshwm sim ntawm ketoconazole yog qhov tseem ceeb nyob rau theem digestive, txawm tias qhov spectrum ntawm qhov tsis zoo tom qab siv qhov no Lub hauv paus ntsiab lus tseem ceeb hauv miv yog cov hauv qab no:
- Anorexia lossis txo qis qab los noj mov
- Vim
- Dab mob plab
- pab mob plab
- Platelets txo
- Neurological cov cim xws li: tshee, ataxia thiab apathy
Jaundice
Qhov tshwm sim ntawm cov kev mob tshwm sim no siab dua yog tias muaj Ketoconazole overdose nyob rau hauv miv Vim li no tsis txhob muab Ketoconazole rau koj tus miv yam tsis muaj. thawj zaug dhau los ntawm kws kho tsiaj cov tshuaj uas koj tus kws kho tsiaj yuav siv cov tshuaj tshwj xeeb rau koj tus menyuam me me raws li nws tus yam ntxwv.
Contraindications ntawm Ketoconazole rau miv
Kev siv ketoconazole hauv miv yog contraindicated nyob rau hauv tag nrho cov nram qab no mob:
- Cats CatsCatsCats
- Cas
- Cats nrog thrombocytopenia: tsawg platelet suav.
- Kittens tsawg dua 1 lub hlis.
- Gatas
- ZIB NIAM NOJ NIAM, COV NTAUB NTAWV YUAV TSUM TAU NROG CARE.
Ketoconazole siv tsis tauthaum koj yog noj tshuaj antacids lossis H2receptor antagonist tshuaj xws li ranitidine lossis cimetidine, nrog rau cov twj tso kua mis proton xws li omeprazole vim cov no ua rau lub plab pH ntau alkaline thiab ketoconazole yuav tsum muaj cov kua qaub nruab nrab rau kev nqus.
Lwm cov tshuaj uas yuav tsum tsis txhob siv ua ke nrog Ketoconazole vim hais tias lawv txo cov kev tshem tawm ntawm lwm yam tshuaj metabolized los ntawm cytochrome P450 yog cov hauv qab no:
- Cyclosporins.
- Cisapride.
- Midazolam.
- Macrolides: clarithromycin, erythromycin.
- Amlodipine.
- Fentanyl.
- Phenobarbital.
- Digoxin.
- Anticoagulants.
- Macrocyclic lactones: ivermectin, selamectin, milbemycin.
- Amitriptyline.
- Theophylline.
- Vincristine.
- Vinblastine.
