Phenobarbital yog ib qho tshuaj antiepileptic tshuaj uas belongs rau pawg ntawm barbiturates. Vim nws txoj kev ua tau zoo, nws raug suav hais tias yog cov tshuaj ntawm thawj qhov kev xaiv los kho mob qaug dab peg los ntawm kev qaug dab peg hauv dev. Txawm li cas los xij, nws cov kev tswj hwm tuaj yeem ua rau muaj kev cuam tshuam ntau yam tsis zoo, uas yog vim li cas nws thiaj li yuav tsum tau saib xyuas cov concentration ntawm cov tshuaj hauv cov ntshav kom ib txwm tswj cov qib hauv cov kev kho mob.
Yog koj xav paub ntau ntxiv txog phenobarbital hauv dev,thiab pom zoo koob tshuaj, tsis txhob yig tau nyeem cov kab lus hauv qab no ntawm peb lub vev xaib uas peb tham txog koob tshuaj thiab cov tshuaj no yog dab tsi rau.
Phenobarbital yog dab tsi?
Phenobarbital yog ib qho tshuaj tiv thaiv kab mob uas muaj nyob hauv tsev neeg barbiturate. Nws yog oldest antiepileptic siv nyob rau hauv veterinary tshuaj thiab suav hais tias yog cov tshuaj thawj qhov kev xaiv rau kev kho mob qaug dab peg hauv dev vim nws muaj peev xwm thiab muaj txiaj ntsig zoo.
Tam sim no muaj hauv ntsiav tshuaj daim ntawv rau kev tswj qhov ncauj hauv dev.
Phenobarbital siv rau dev yog dab tsi?
Phenobarbital hauv dev yog siv los tiv thaiv qaug dab pegRaws li kev qhia meej, peb yuav hais tias qaug dab peg muaj kev hloov pauv ntawm cov lub paj hlwb ua haujlwm yam ntxwv los ntawm lub caij nyoog, rov tshwm sim, thiab tsis tuaj yeem tshwm sim ntawm qaug dab peg. Cov qaug dab peg no tshwm sim los ntawm kev tsis sib haum xeeb thiab kev sib raug zoo ntawm cortical neurons, uas ua rau muaj kev cuam tshuam hluav taws xob synchronous. Yog xav paub ntxiv, tsis txhob nco lwm tsab xov xwm ntawm Epilepsy hauv dev, ua rau, tsos mob thiab kev kho mob.
Tag nrho cov tshuaj tiv thaiv kab mob, suav nrog phenobarbital, ua raws li lawv cov txheej txheem ntawm kev ua ntawm stabilizing lub neuronal membrane yog li tiv thaiv nws excitement. Ntawd yog, lawv txwv tsis pub tshaj cov hluav taws xob neuronal los tiv thaiv qhov pib ntawm qaug dab peg. Tshwj xeeb, cov nyhuv anticonvulsant ntawm phenobarbital yog vim qhov tseeb tias nws txhim kho qhov kev txiav txim ntawm neurotransmitter GABA, lub ntsiab inhibitory neurotransmitter ntawm Central Nervous System.
Nws yuav tsum tau muab sau tseg tias txawm hais tias cov tshuaj tiv thaiv kab mob yog siv los kho mob qaug dab peg, lawv tsuas yog kho mob . Qhov no txhais tau tias tsis kho mob qaug dab peg, tab sis tsuas yog txo nws cov tsos mob (qaug dab peg).
Thaum twg thiaj pib tswj phenobarbital hauv dev?
Txawm tias muaj tseeb hais tias, nyob rau hauv veterinary tshuaj, tsis muaj kev pom zoo rau thaum twg antiepileptic kev kho mob yuav tsum pib, feem ntau cov kev tshawb fawb txog qhov no pom zoo kom pib kho thaum twg ib yam ntawm cov nram qab no cov txheej txheem:
- Thaum 2 qaug dab peg nyob rau 6 hli.
- Muaj Qhov Ua Raws Li Tus qaug dab peg) xws li kev txom nyem los yog dig muag. Tsis tas li ntawd thaum cov paib postictal muaj lub sijhawm sib npaug lossis ntau dua 24 teev.
- Thaum qaug dab peg, uas feem ntau hu ua “ cluster seizures”. Qhov kev ntsuas no yuav tsum tau txiav txim siab txawm tias qaug dab peg 2-3 teev sib nrug.
- Thaum lub sij hawm interictal luv, uas yog, lub sij hawm ntawm ib tug qaug dab peg thiab lwm yam.
Thaum muaj kev kub ntxhov hnyav, hauv tsab xov xwm no peb piav qhia yuav ua li cas txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm
Dog Phenobarbital Dosage
thawj koob tshuaj phenobarbital yuav tsum yog 2-5 mg ib kg ntawm lub cev hnyav ib hnub. Qhov koob tshuaj no yuav tsum muab faib thiab muab ob zaug ib hnub.
Vim cov kev mob tshwm sim uas peb yuav pom tom qab, nws yog ib qho tseem ceeb rau thiab khaws cia rau hauv qhov kev kho mob. Raws li cov ntshav siab ntawm phenobarbital tsis ncav cuag lub xeev ruaj khov mus txog 2 lub lis piam tom qab pib kho, koob tshuaj yuav tsum tsis txhob hloov kho lub sijhawm no. Tom qab ntawd, qib ntshav qab zib yuav tsum tau saib xyuas txhua 6 lub hlis. Feem ntau, plasma concentration ntawm phenobarbital hauv cov ntshav yuav tsum nyob nruab nrab ntawm 15 thiab 40 µg / ml, nrog qhov zoo tshaj plaws nyob ib ncig ntawm 30 µg / ml.
Tom qab pib kev kho mob nrog phenobarbital, cov xwm txheej hauv qab no yuav tshwm sim:
- Tus neeg mob qaug dab peg yog tswj tau tab sis tus neeg mob mob hnyav heev: nyob rau hauv cov ntaub ntawv no, koj tus kws kho tsiaj tej zaum yuav txo cov koob tshuaj phenobarbital los yog tos ob peb. hnub rau qib tshuaj kom sib npaug hauv cov ntshav.
- Epilepsy is not controlled: Yog hais tias qaug dab peg ntxiv, koj tus kws kho tsiaj yuav ntsuas cov qib phenobarbital hauv cov ntshav los txiav txim seb yuav txiav txim siab li cas. Yog tias qib qis, koob tshuaj phenobarbital tuaj yeem nce ntxiv. Yog tias cov qib nyob hauv qhov qub, phenobarbital tuaj yeem ua ke nrog lwm cov tshuaj tiv thaiv kab mob, xws li potassium bromide lossis imepitoin.
- Tus mob qaug dab peg tau tswj tau, tab sis nyob rau qee lub sijhawm cov teeb meem convulsive rov tshwm sim: Ib yam li ntawd, qhov no theem ntawm phenobarbital los txiav txim seb puas yog. kom nce koob los yog muab sib xyaw nrog lwm cov tshuaj tiv thaiv kab mob.
Phenobarbital overdose hauv dev
Phenobarbital overdose nyob rau hauv dev feem ntau tshwm sim los ntawm accidental ingestion ntawm cov tshuaj. Qhov no yog ib qho mob hnyav heev uas cov hauv qab no cov tsos mob: yuav tshwm sim
- Central nervous system depression, uas tuaj yeem ua rau qaug zog mus rau coma.
- Cov teeb meem plawv, hypotension thiab anaphylactic shock, uas tuaj yeem ua rau lub raum tsis ua haujlwm thiab tuag ntawm tus tsiaj.
Tau qhov mob hnyav ntawm phenobarbital overdose, nws yog ib qho tseem ceeb kom sai li sai tau qhov kev mob tshwm sim tau raug kuaj pom lossis xav tias, koj mus rau qhov chaw kho tsiaj sai sai los tiv thaiv kev nqus tshuaj thiab muab kev pab ua pa thiab mob plawv thaum xav tau. Txawm hais tias tsis muaj cov tshuaj tiv thaiv tshwj xeeb rau qhov kev qaug cawv no, cov tshuaj stimulants hauv nruab nrab paj hlwb, xws li Doxapram, tuaj yeem pab txhawb lub chaw ua pa.
Txawm li cas los xij, nco ntsoov qhov tseem ceeb ntawm khaws txhua yam tshuaj kom deb ntawm koj cov tsiaj, vim nws yuav yog txoj hauv kev zoo tshaj plaws zam txim los ntawm kev noj tshuaj tsis haum.
Side Effects of Phenobarbital rau dev
Cov kev mob tshwm sim feem ntau cuam tshuam nrog phenobarbital tshwm sim thaum pib kho lossis tom qab noj tshuaj ntxiv, thiab feem ntau txhim kho lossis ploj tom qab 1-2 lub lis piam. Tom ntej no, peb sau cov txiaj ntsig tseem ceeb ntawm phenobarbital hauv dev:
- Polyuria: nce zis ntim.
- Polydipsia: nce dej haus.
- Polyphagia: noj zaub mov ntau ntxiv.
- Sedation and ataxia.
- Hepatotoxicity: nyob rau hauv kev kho mob ntev, yuav tsum tau saib xyuas cov kab mob siab (lub siab enzymes thiab bile acids) yuav tsum tau saib xyuas.
- Cytopenias: txo cov qe ntshav.
- Reduction T4 los yog thyroxine ntau ntau: Txawm li cas los xij, cov qib rov qab los li qub 4-6 lub lis piam tom qab tso tseg kev kho mob nrog phenobarbital.
Ntau yam tsawg dua, lwm yam kev mob tshwm sim yuav tshwm sim xws li superficial necrolytic dermatitis, pancreatitis, thiab dyskinesia (txawv txav, txav tsis tau).
Contraindications of phenobarbital rau dev
Txawm hais tias nws yog ib qho tshuaj zoo heev, muaj qee qhov xwm txheej uas kev tswj hwm ntawm phenobarbital yuav tsis pom zoo. Lub ntsiab contraindications ntawm phenobarbital hauv dev yog:
-Tam Sim No Tsis Txhob Kho Mob NATION
Ntxiv rau, txawm hais tias nws siv tsis yog contraindicated thaum lub sij hawm cev xeeb tub thiab lactation, nws yuav tsum tau siv nrog ceev faj nyob rau hauv cov xwm txheej physiological:
- Phenobarbital muaj peev xwm hla lub placental barrier, uas tuaj yeem cuam tshuam rau kev loj hlob ntawm cov menyuam dev thiab nyiam cov hemorrhage neonatal. Txawm li cas los xij, yog tias tus kws kho tsiaj txiav txim siab tias cov txiaj ntsig ntawm kev kho mob ntau dua qhov txaus ntshai, cov tshuaj yuav raug muab rau cov menyuam mos cev xeeb tub.
- Phenobarbital raug tso tawm me me hauv cov kua mis thiab yuav ua rau muaj kev ntxhov siab hauv cov menyuam dev. Hauv cov xwm txheej no, koj tuaj yeem xaiv qhov kev txiav tawm ntxov thiab pub lub raj mis pub mis.
