Metamizole yog ib yam tshuaj uas muaj analgesic, antipyretic thiab antispasmodic effect, uas yog dav siv nyob rau hauv tib neeg thiab veterinary tshuaj. Tam sim no, tib cov tshuaj kws kho tsiaj uas muaj cov khoom xyaw nquag no yog nyob rau hauv daim ntawv ntawm kev txhaj tshuaj. Txawm li cas los xij, muaj lwm cov qauv tsim los siv rau cov neeg uas tej zaum yuav raug sau los ntawm koj tus kws kho tsiaj thaum nws pom tias tsim nyog.
Yog koj xav paub ntau ntxiv txog metamizol rau dev, tsis txhob nco cov lus hauv qab no ntawm peb qhov chaw uas peb tham txog nws dose, nws yog dab tsi rau thiab phiv.
metamizol yog dab tsi?
Metamizole los yog metamizole sodium yog ib yam tshuaj uas muaj nyob rau hauv pawg ntawm pyrazolone derivatives siv los ua tus neeg sawv cev analgesic, antipyretic thiab spasmolytic.
Tam sim no, metamizole sodium puas tuaj yeem muab rau tus dev? Cov lus teb yog yog, tab sis ib txwm nyob hauv cov lus qhia kws kho tsiaj. Qhov tseeb, metamizol yog cov khoom muaj npe nrov ntawm "Nolotil", feem ntau siv hauv tib neeg cov tshuaj los kho mob me me lossis mob hnyav thiab tswj cov mob kub taub hau refractory rau lwm cov tshuaj. Txawm li cas los xij, muaj cov tshuaj kho tsiaj tshwj xeeb uas kuj suav nrog metamizole ua cov khoom xyaw nquag. Kom meej meej, metamizole sodium hauv dev muaj
Zoo li lwm yam tshuaj, metamizole yuav tsum tau muab los ntawm kws kho tsiaj. Tsis tas li ntawd, raws li nws xav tau kev tswj xyuas parenteral (txhaj tshuaj los yog intramuscular), nws yuav tsum tau muab los ntawm kws kho tsiaj lossis kws kho tsiaj pab.
metamizol siv rau dev yog dab tsi?
Raws li peb tau npaj tseg hauv ntu dhau los, metamizol muaj peb yam tseem ceeb: tshuaj tua kab mob, tshuaj tua kab mob thiab spasmolytic. Tom ntej no, peb yuav piav qhia txhua yam ntawm cov teebmeem no thiab peb yuav pom nyob rau hauv cov xwm txheej uas lawv cov thawj coj tuaj yeem tau txais txiaj ntsig.
Analgesic effect
Metamizole yog ib yam tshuaj uas muaj cov nyhuv analgesic uas yog siv los txo qhov mob nruab nrab mus rau hnyav. Cov nyhuv no yog tsim ua tsaug rau lub zog blockade ntawm enzyme cyclo-oxygenase (COX-3) thiab ua kom cov opioid thiab cannabinoid systems.
Nws cov nyhuv analgesic tso cai rau siv cov tshuaj no nyob rau hauv multimodal analgesia, uas muaj ib txhij siv ntawm ntau hom tshuaj analgesics uas lawv ua rau cov receptors sib txawv thiab kev sib kis, nrog rau lub hom phiaj ntawm kev tswj qhov mob zoo dua. Tshwj xeeb, metamizole sodium hauv dev tuaj yeem ua ke nrog NSAIDs thiab opioids, yog li tso cai rau cov koob tshuaj ntawm txhua cov tshuaj txo qis, thiab yog li nws cov kev mob tshwm sim. Tsis tas li ntawd, nws tau pom tias muaj kev sib koom ua ke nrog lwm cov tshuaj tua kab mob, xws li morphine lossis ketoprofen.
tshwj xeeb, metamizol yog siv los tswj:
- Visceral mob: tshwj xeeb tshaj yog mob colic.
- Postoperative mob.
- Pab mob txuam nrog rau cov musculoskeletal system: xws li, piv txwv li, mob txuam nrog mob caj dab, mob rheumatic, neuralgia los yog mob nraub qaum..
Ib qho tseem ceeb ntawm metamizol yog tias nws qhov kev txiav txim tsis cuam tshuam txog kev tsim cov prostaglandins, yog li nws tsis tsim cov txiaj ntsig tsis zoo ntawm NSAIDs (xws li mob plab lossis raum tsis ua haujlwm). Yog li, nws tuaj yeem suav tias yog lwm txoj hauv kev zoo rau cov neeg mob uas siv NSAIDs yog contraindicated.
Cov nyhuv Antipyretic
Metamizole kuj muaj cov nyhuv antipyretic, uas yog, nws txo qhov kub taub hau Txawm hais tias cov tshuaj tua kab mob ntawm kev ua haujlwm tsis tau txhais, muaj. pov thawj qhia tias qhov no tshwm sim los ntawm txoj kev ywj pheej ntawm prostaglandin blockade.
Feem ntau, metamizole tuaj yeem siv tau nyob rau hauv ib qho mob febrile, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob uas refractory rau lwm yam tshuaj antipyretic.
Spasmolytic lossis antispasmodic effect
Kawg, tab sis tsis kawg, metamizol hauv dev muaj cov nyhuv spasmolytic los yog antispasmodic, uas txhais tau hais tias nws relaxes cov nqaij ntshiv nyob rau hauv lub plab zom mov, urinary ib ntsuj av, biliary thiab lwm yam. Cov nyhuv antispasmodic no tau piav qhia los ntawm txo qis hauv inositol phosphate synthesis, uas ua rau txo qis hauv intracellular calcium tso tawm.
Vim nws cov tshuaj antispasmodic, metamizol feem ntau siv rau cov dev nrog plab hnyuv, biliary los yog urinary colic.
noj tshuaj metamizole rau dev
Tam sim no, metamizole rau dev tsuas yog muaj raws li tshuaj txhajrau kev txhaj tshuaj los yog intramuscular.
koob tshuaj metamizole rau dev yuav tsum yog 20 mus rau 50 mg ntawm metamizole sodium ib kilogram ntawm lub cev qhov hnyav Cov koob tshuaj no tuaj yeem muab tshuaj maj mam muab tso rau hauv cov leeg lossis sib sib zog nqus intramuscularly, tab sis tsis yog subcutaneously vim kev khaus hauv zos yuav tshwm sim.
Ntau dhau ntawm metamizole sodium hauv dev
Cov neeg mob metamizole sodium overdose hauv dev tau tshaj tawm ntawm cov koob tshuaj ntau heev, txij li 1,000 txog 4,000 mg / kg lub cev hnyav. Metamizol lom nyob rau hauv dev cuam tshuam rau hauv nruab nrab paj hlwb, ua rau cov tsos mob xws li sedation thiab qaug dab peg. Thaum noj tshuaj ntau dhau, nws yuav tsim nyog los tsim kev txhawb nqa kev kho mob thiab tswj cov kev ntxhov siab nrog rau cov tshuaj diazepam.
Cov teebmeem ntawm metamizol hauv dev
Txawm hais tias cov neeg mob leukopenia, agranulocytosis thiab aplastic anemia tau raug tshaj tawm rau tib neeg vim kev siv metamizol, hauv cov kws kho tsiaj tsis muaj lus ceeb toom txog qhov muaj cov tshuaj no lossis lwm yam tshuaj lom hematological tshwm sim los ntawm metamizol. Qhov tseeb, daim ntawv teev cov ntaub ntawv rau metamizole does not description any adverse reaction txuam nrog kev siv cov tshuaj no.
Contraindications ntawm metamizol hauv dev
Txawm hais tias metamizole yog cov tshuaj muaj kev nyab xeeb, muaj qee qhov xwm txheej uas nws cov thawj coj tuaj yeem cuam tshuam. Tshwj xeeb, metamizol sodium hauv dev yog contraindicated nyob rau hauv cov ntaub ntawv hauv qab no:
- Allergy or hypersensitivity to metamizol los yog rau ib qho khoom noj uas muaj cov khoom xyaw nquag.
- Heart failure, Hepatic orraum.
Nws yuav tsum raug sau tseg tias kev tshawb fawb hauv cov tsiaj sim tsis tau pom tias metamizole tsim cov tshuaj teratogenic lossis tshuaj lom rau cov menyuam hauv plab. Txawm li cas los xij, nws raug pom zoo kom siv nrog ceev faj thaum cev xeeb tub thiab lactating bitches vim muaj pov thawj ntau ntxiv los ua pov thawj kev nyab xeeb ntawm cov tshuaj nyob rau theem no.
