Txog rau thaum xaus ntawm lub xyoo pua xeem, Cushing's syndrome hauv dev tau kho nrog tshuaj hu ua mitotane, uas muaj qhov tsis zoo ntawm kev ua kom cov qog adrenal. Txawm li cas los xij, kev tshawb fawb hnyav rau lwm txoj kev kho mob coj mus rau kev txhim kho cov tshuaj muaj kev nyab xeeb thiab zoo dua, trilostane.
Yog koj xav paub ntau ntxiv txog trilostane hauv dev, suav nrog nws noj tshuaj thiab cov kev mob tshwm sim, tsis txhob nco tsab xov xwm tom ntej ntawm peb qhov chaw.
Trilostane yog dab tsi?
Trilostane yog cov tshuaj steroid hormone analogue uas inhibits lub enzyme lub luag hauj lwm rau synthesizing adrenal hormones, tshwj xeeb tshaj yog cortisol thiab aldosterone. Qhov no ua rau nws ib qho tshuaj zoo rau kev kho mob hyperadrenocorticism los yog Cushing's syndrome, ib qho kab mob endocrine uas tshwm sim los ntawm qhov muaj mob ntev thiab ntau dhau ntawm cortisol thiab aldosterone.
Tam sim no, cov tshuaj yog muaj raws li cov tshuaj ntsiav nyuaj ntawm 5, 10, 30, 60 thiab 120 mg. Tus nqi ntawm trilostane rau dev txawv nyob ntawm seb qhov concentration. Raws li kev siv, tus nqi ntawm txhua 60 mg capsule ranges ntawm € 1.5 thiab € 2.
Trilostane siv rau dev dab tsi?
Koj puas xav paub tias Cushing's syndrome hauv dev kho tau li cas? Zoo, koj yuav tsum paub tias trilostane yog cov tshuaj ntawm kev xaiv rau kev kho mob ntawm tus kab mob no. Tshwj xeeb tshaj yog, yog siv los ua ib qho kev kho mob ntawm Cushing's pituitary keeb kwm, thiab ua ke nrog kev phais hauv cov ntaub ntawv ntawm Cushing's ntawm adrenal keeb kwm.
Trilostan dosage for dev
The pib koob tshuaj rau kev kho mob ntawm Cushing's syndrome yog 2 mg/kg lub cev hnyav Cov koob tshuaj tuaj yeem muab txhua 24 teev, txawm hais tias kom tau txais cov lus teb zoo dua, nws raug nquahu kom faib cov koob tshuaj rau ob zaug ib hnub. Los ntawm thawj koob tshuaj no, koj yuav tsum saib xyuas tus tsiaj cov lus teb thiab kho qhov koob tshuaj raws li nws:
- Cov tsos mob tshwm sim ntawm Cushing's (kev haus dej ntau ntxiv, tso zis ntau ntxiv, nce qab los noj mov thiab panting), txhais tau hais tias qhov koob tshuaj trilostane tsis txaus, yog li nws yuav tsum tau nce koob.
- Cov tsos mob ntawm Addisonian cov tsos mob (anti-Cushing's syndrome tshwm sim los ntawm ntuav, raws plab, tsis muaj zog, tsis muaj zog), txhais tau hais tias koob tshuaj trilostane ntau dhau, uas yog vim li cas nws thiaj li yuav tsum tau txo cov koob tshuaj.
- Yog tias tsis muaj cov tsos mob tshwm sim, nws txhais tau hais tias cov koob tshuaj tau zoo tau mus txog uas tso cai rau kev tswj xyuas kab mob zoo.
Kev tshuaj xyuas txog kev hloov koob tshuaj yuav tsum tau ua txhua lub lim tiam, hli, 3 lub hlis thiab, tom qab, txhua 3-6 lub hlis. Nws yuav tsum tau muab sau tseg tias kev hloov koob tshuaj yuav tsum tau muab tshuaj los ntawm kws kho tsiaj.
Yuav ua li cas tswj Trilostane hauv dev?
Thaum paub txog koob tshuaj, nws yog ib qho tseem ceeb uas yuav tau taw qhia seb yuav siv tshuaj trilostane rau dev li cas:
- Cov tshuaj los ntawm cov tshuaj ntsiav nyuaj, yog li nws yuav tsum tau muab tshuaj orally, nrog zaub mov.
- Cov tshuaj ntsiav yuav tsum tsis txhob qhib lossis faib, vim cov ntsiab lus yuav ua rau tawv nqaij thiab qhov muag khaus.
- Nws yuav tsum tau hais tias trilostane muaj cov tshuaj tiv thaiv progesterone, yog li cov poj niam uas cev xeeb tub los yog xav xeeb tub yuav tsum tsis txhob tiv tauj nrog tshuaj ntsiav.
Trilostane phiv hauv dev
Trilostane yog ib yam tshuaj muaj kev nyab xeeb, txawm li cas los xij, qee qhov kev phiv tshwm sim uas yuav tsum paub txog muaj nyob hauv nws daim ntawv qhia kev:
- Thaum cov koob tshuaj tsim nyog tshaj, cov tsos mob txuam nrog hypoadrenocorticism (Addison's syndrome) tshwm sim, xws li kiv taub hau, lethargy, anorexia, ntuav., raws plab. Feem ntau, cov tsos mob no rov qab los tom qab tshem tawm kev kho mob.
- In case of overdose an acute Addisonian ntsoog yuav tshwm sim.
- Ntau zaus, ataxia (incoordination), hypersalivation, o, nqaij tremors thiab daim tawv nqaij hloov yuav tshwm sim.
- Ib tug ob peb tus neeg raug rho tawm ntawm necrosis ntawm qog adrenal tau tshaj tawm.
Ntxiv rau, nws yuav tsum tau muab sau tseg tias kev kho mob nrog trilostane tuaj yeem ua rau lub raum tsis ua haujlwm lossis mob caj dab.
Contraindications ntawm Trilostane rau dev
Trilostane kev tswj hwm yog contraindicated nyob rau hauv cov xwm txheej hauv qab no:
- Dog under 3 kg.
- Allergy or hypersensitivity to trilostane los yog ib qho ntawm cov excipients uas nrog cov khoom xyaw nquag.
- Kev kho mob tsis ntev los no nrog mitotane: ib lub hlis twg yuav tsum tau saib xyuas ntawm kev txiav txim siab ntawm kev tswj hwm mitotane thiab pib kho nrog trilostane.
Teb Tsis Tau
Tsis tas li ntawd, trilostane yuav tsum tau noj nrog kev ceev faj tshwj xeeb hauv cov xwm txheej hauv qab no:
- : Cov kab mob siab thiab lub raum (lub siab enzymes, electrolytes, urea, thiab creatinine) yuav tsum tau saib xyuas kom tsis txhob mob siab lossis lub raum tsis ua haujlwm, feem ntau ntawm cov dev laus.
- Diabetes mellitus: Cushing's syndrome and diabetes yuav tsum tau saib xyuas tshwj xeeb
- Anemia: ntshav cell ntim thiab hemoglobin yuav tsum tau saib xyuas vim trilostane tuaj yeem ua rau txo qis hauv cov ntsuas no.
(Angiotensic-(angiotensin-converting enzyme inibitors)
