Enantyum yog ib yam tshuaj uas nws muaj active ingredient yog dexketoprofen. Nws belongs rau tsev neeg ntawm NSAIDs (non-steroidal anti-inflammatory tshuaj), yog li nws yog tus cwj pwm los ntawm kev muab cov tshuaj analgesic, anti-inflammatory thiab antipyretic nyhuv. Nyob rau hauv Spain, nws muaj nyob rau hauv ntau qhov ncauj thiab parenteral formulations rau siv nyob rau hauv tib neeg, txawm hais tias koj tus kws kho tsiaj tej zaum yuav sau cov tshuaj no rau koj tus dev thaum nws pom tias nws tsim nyog.
Yog xav paub ntxiv txog kev siv Enantyum in dogs, tsis txhob nco cov lus hauv qab no ntawm peb qhov chaw uas peb piav qhia nws txoj kev siv, ntau npaum li cas, phiv thiab contraindications.
Enantyum yog dab tsi?
Peb paub Enantyum ua lub npe lag luam ntawm cov tshuaj uas nws cov khoom muaj nqis yog dexketoprofen. Hais tias dexketoprofen belongs rau tsev neeg ntawm NSAIDs (Non-Steroidal Anti-Inflammatory Drugs). Cov tshuaj no muaj 3 cov teebmeem tseem ceeb: analgesic effect (lawv kho mob me-mob), anti-inflammatory and antipyretic Cov teebmeem no tshwm sim vim NSAIDs ua los ntawm inhibiting enzyme cyclooxygenase (COX). Raws li qhov tshwm sim, thaum peb muab lawv, cov cellular mediators (prostaglandins, prostacyclins thiab thromboxanes) uas cuam tshuam rau qhov tshwm sim ntawm qhov mob, mob thiab ua npaws tsis tsim. Li no, NSAIDs yog siv feem ntau los kho peb cov tsos mob no.
Enantyum is available in various formulations, ob qhov ncauj thiab parenteral. Cov tshuaj hauv qhov ncauj muaj xws li ntsiav tshuaj, tshuaj ntsiav, thiab granules rau kev daws qhov ncauj. Parenteral formulations tuaj nyob rau hauv daim ntawv ntawm ampoules thiab yuav muab intramuscularly los yog intravenously (los ntawm infusion los yog bolus).
Yog koj xav paub ntau ntxiv txog tshuaj tiv thaiv kab mob, tsis txhob yig mus nyeem cov kab lus no ntawm peb lub vev xaib Kuv puas tuaj yeem muab kuv tus dev tshuaj tiv thaiv kab mob?
Enantyum siv rau dev
Nyob hauv Spain, Enantyum muaj nyob rau hauv ntau qhov ncauj thiab parenteral formulations rau siv rau tib neeg, tab sis nws tsis yog marketed rau siv nyob rau hauv dev. Txawm li cas los xij, koj tus kws kho tsiaj tuaj yeem sau cov tshuaj no rau koj tus dev nyob ntawm qhov xwm txheej:
NATION NOJ QAB ZAUB LOS NTAWM CASCADED CAPTEDIC YOOJ YIM, nws yog qhov tshuaj uas yog, nws yog cov tshuaj uas yog tsis tau tso cai rau ib hom tsiaj tshwj xeeb, thaum tsis muaj cov tshuaj tsim nyog los kho cov kab mob tshwj xeeb hauv ib hom kab mob tshwj xeeb. Yog li ntawd, koj tus kws kho tsiaj feem ntau yuav siv tshuaj nrog cov teebmeem zoo ib yam li Enantyum, uas tau tso cai rau hauv cov tsiaj canine, thiab tsuas yog siv cov tshuaj cascade ntawm Enantyum thaum tsis muaj lwm yam kev kho mob.
Hauv qhov tshwj xeeb ntawm dexketoprofen, cov kev tshawb fawb uas tau sim nws cov kev ua tau zoo hauv cov dev tau pom tias nws yog cov tshuaj uas muab zoo perioperative analgesia Los ntawm kev sib piv nws cov nyhuv analgesic nrog cov tshuaj opioids xws li bruprenorphine, tramadol lossis methadone, nws tau txiav txim siab tias cov nyhuv analgesic muab rau lub sijhawm tom qab phais tsis zoo dua li cov tshuaj opioids.
Tsis tas li ntawd, nws cov thawj coj thaum lub sij hawm tshuaj loog premedication tsis txhais hais tias yuav tsum tau ntau dua rau inhalation analgesia los yog intraoperative analgesia. Txawm li cas los xij, nws tsis muaj cov nyhuv sedative tuaj yeem ua rau dysphoric (mob heev) tsaug zog tom qab tshuaj loog, yog li nws raug nquahu kom siv tshuaj sedative thaum lub sij hawm tshuaj loog rov qab kom tsis txhob muaj qhov teeb meem no.
Yog koj xav tias koj tus dev yuav mob, peb xav kom koj mus ntsib kws kho tsiaj ua ntej. Koj tuaj yeem saib cov kab lus no ntawm Cov tsos mob ntawm tus dev mob.
Enantyum dosage for dogs
Muab hais tias Enantyum yog ib qho tshuaj tsim tshwj xeeb rau tib neeg, nws cov ntaub ntawv tsuas yog suav nrog cov tshuaj pom zoo rau tib neeg. Txawm li cas los xij, cov kev tshawb fawb uas lees paub qhov ua tau zoo ntawm dexketoprofen hauv cov dev tso cai rau peb txiav txim siab seb qhov koob tshuaj zoo li cas ntawm cov tshuaj no tuaj yeem muaj nyob hauv hom no. Ib yam li ntawd, nws yuav tsum nco ntsoov tias, txhawm rau qhia qhov koob tshuaj ntawm Enantyum uas peb tus dev xav tau, peb yuav tsum coj mus rau hauv tus account txoj kev ntawm kev tswj hwm, nws tus mob thiab yog vim li cas rau cov tshuaj. Ua li no, peb hais kom tsuas yog tus kws kho tsiaj tuaj yeem sau tshuaj kho nrog Enantyum.
Studies using Enantyum intravenously in anesthetic premedication ntawm cov dev mus phais, muab tshuaj 1 mg /kgCov kev tshawb fawb hais tias, ntxiv rau kev tswj hwm Enantyum hauv kev kho mob ua ntej, ncua kev mob ntshav qab zib nrog cov tshuaj tib yam, tswj cov koob tshuaj ntawm 1 mg / kg txhua 8 teev. Muab hais tias cov kev tshawb fawb no siv cov koob tshuaj no ua kom muaj txiaj ntsig zoo perioperative analgesia, peb tuaj yeem xav tias nws yog ib qho tshuaj txhaj zoo.
Ntawm qhov tod tes, kev tswj hwm ntawm Enantyum orally hauv dev tsuas yog raug tshuaj xyuas hauv ib txoj kev tshawb fawb. Hauv txoj kev tshawb no, uas cov tshuaj pharmacokinetics ntawm Enantyum raug tshuaj xyuas, lawv muab cov koob tshuaj 1 thiab 3 mg / kg ntawm qhov ncauj thiab xaus lus tias ob koob tshuaj muaj kev nyab xeeb (tsis muaj kev phiv tshwm sim) thiab tej zaum yuav siv tau rau dev. Txawm li cas los xij, lawv taw qhia tias kev sim tshuaj ntau dua yog qhov tsim nyog los ntsuas qhov pom ntawm qhov ncauj ntawm cov dev.
Txawm li cas los xij, txhawm rau zam cov kev mob tshwm sim ntawm cov tshuaj no, koob tshuaj yuav tsum tau hloov kho kom txog thaum koob tshuaj tsawg kawg nkaus tau txais rau txhua tus neeg mob, nkag siab tias qhov no yuav tsawg dua qhov koob tshuaj pom zoo thiab nws yuav txawv raws sijhawm. Txhawm rau ua qhov no, qhov ua tau zoo ntawm kev kho mob yuav raug ntsuas raws li cov koob tshuaj lossis zaus ntawm kev txhaj tshuaj raug txo. Tsis tas li, nyob rau hauv cov neeg mob hnyav, qhov koob tshuaj yuav tsum tau xam raws li lub cev hnyav(tsis yog koj qhov hnyav tiag tiag).
NOJ QAB HAUS TSEEM CEEB YUAV TSUM TAU TXAIS KOJ SAIB QHOV QHOV NO RAU PEB LUB CAIJ NO PEB YUAV TSUM UA NTEJ RAU DOGS.
Enantyum phiv hauv dev
Raws li peb tau hais, NSAIDs ua los ntawm inhibiting enzyme cyclooxygenase (COX). Tshwj xeeb, lawv inhibit ob isoforms ntawm no enzyme (COX-1 thiab COX-2). COX-2 enzyme pab txhawb rau kev sib txuas ntawm cellular mediators uas koom nrog qhov pib mob, ua npaws thiab o, yog li nws inhibition yog qhov zoo. Ntawd yog, cov teebmeem kev kho mob ntawm NSAIDs nyob ntawm lawv lub peev xwm los inhibit COX-2. Ntawm qhov tsis sib xws, enzyme COX-1 tso cai rau cov synthesis ntawm cellular mediators uas cuam tshuam rau hauv cov txheej txheem ntawm gastro-tiv thaiv, nephro-tiv thaiv, homeostasis (autoregulation) ntawm coagulation thiab vascular system, thiab lwm yam kev tiv thaiv mechanisms. Yog li ntawd, cov inhibition ntawm COX-1 yuav muaj qhov tsis zoolos yog, lwm yam, cov kev phiv ntawm NSAIDs nyob ntawm seb lawv lub peev xwm los inhibit COX-1..
Hauv qab no, peb sau cov kev mob tshwm sim tseem ceeb ntawm NSAIDs xws li Enantyum:
- : lawv ua rau cov hlwb parietal ua rau mob edema, hemorrhage thiab cell necrosis. Tsis tas li ntawd, lawv txo cov ntshav mus rau lub plab mucosa, txo cov txheej txheem tiv thaiv (mucus thiab bicarbonate) thiab ua rau kom cov khoom tsis zoo (hydrochloric acid thiab pepsin). Yog li ntawd, lawv nyiam cov tsos mob ntawm gastritis, ulcers thiab perforations, uas ua rau cov tsos mob xws li mob plab, xeev siab, anorexia thiab raws plab.
- : lawv txo cov ntshav mus rau lub raum thiab ua kom lub raum ceev ceev. Yog li ntawd, lub raum ua haujlwm txo qis ua rau lub raum tsis ua haujlwm. Ntawm no peb tso koj cov lus qhia ntxiv txog lub raum tsis ua haujlwm hauv dev - Cov tsos mob thiab kev kho mob.
- Hepatic level: nws siv ntau dhau thiab txuas ntxiv ua rau cov kab mob hepatocellular puas, nrog rau qhov nce hauv hepatic transaminases. Nyob rau hauv qhov xwm txheej ntawm qhov nce ntxiv ntawm daim siab cov ntsuas no, kev kho mob yuav tsum tau txiav.
- : lawv inhibit platelet aggregation, ua rau muaj kev pheej hmoo ntawm bruising thiab los ntshav.
- Ntawm cov ntaub so ntswg perfusion: lawv tiv thaiv kev kho kom raug ntawm cov ntshav perfusion nyob rau hauv lub cev sib txawv.
- Respiratory: tuaj yeem ua rau mob hawb pob lossis bronchospasm, tshwj xeeb tshaj yog rau cov neeg mob ua xua rau NSAIDs.
Kuv tus dev noj Enantyum
Yog tias koj tus dev tau noj ib qho Enantyum, nws yog ib qho tseem ceeb uas koj yuav tsum tau mus ntsib koj tus kws kho tsiaj sai li sai tau thiab qhia nws qhov kev nthuav qhia (cov ntsiav tshuaj, ntsiav tshuaj, thiab lwm yam.) muaj Enantyum uas koj tau noj thiab ntau npaum li cas koj tau noj. Nyob ntawm qhov kev nthuav qhia, koob tshuaj ntawm txhua ntsiav tshuaj / tshuaj ntsiav tuaj yeem yog 12, 5 mg lossis 25 mg. Nws yog ib qho tseem ceeb uas koj muab cov ntaub ntawv no rau koj tus kws kho tsiaj kom nws tuaj yeem soj ntsuam cov qib ntawm kev noj tshuaj ntau dhau raws li koj tus dev qhov hnyav thiab cov koob tshuaj uas nws tau noj. Nyob rau hauv cov ntaub ntawv ntawm overdose, cov kev mob tshwm sim tau piav qhia saum toj no yuav txhim kho. Yog li ntawd, koj yuav tsum nco ntsoov qhov tseem ceeb ntawm khaws txhua yam tshuaj kom deb ntawm koj cov tsiaj kom tsis txhob noj khoom txom nyem.
Contraindications ntawm enantyum nyob rau hauv dev
Cov contraindications ntawm Enantyum nyob rau hauv dev muab los ntawm nws cov teebmeem thib ob. Yog li, xav txog cov kev mob tshwm sim uas tau piav qhia saum toj no, Enantyum yuav raug txwv tsis pub siv rau hauv cov xwm txheej hauv qab no:
- Dog nrog digestive pathologies xws li mob plab lossis kab mob plab.
- Dog nrog raum pathologies los yog nyob rau hauv kev kho mob uas cuam tshuam rau lub raum kev ua haujlwm: xeev ntawm lub raum tsis ua haujlwm (congestive heart failure, hypotension), glomerulonephritis, geriatric tsiaj kho nrog ACE inhibitors (Angiotensin Converting Enzyme Inhibitors) los yog ASA diuretics.
- Dab siab tsis zoo. Peb tso koj zaj lus no hais txog lub siab tsis ua hauj lwm rau cov dev kom koj thiaj paub ntxiv txog nws.
- Dog nrog coagulopathies (coagulation disorders), uas yog nyob rau hauv perioperative lub sij hawm (kev kho mob nrog NSAIDs yuav tsum tau cuam tshuam li 10 -14 hnub ua ntej. phais).
- Dog tau txais lwm yam kev kho mob uas yuav hloov hemostasis (xws li heparin lossis warfarin).
- Dog uas muaj kab mob perfusionvim yog hypovolemia, hypotension, lub cev qhuav dej lossis poob siab. Hauv cov xwm txheej no, kev tswj hwm ntawm NSAIDs ntxiv qhov kev pheej hmoo ntawm nephrotoxicity.
Tam sim no koj paub ntau ntxiv txog Enantyum hauv dev, tej zaum koj yuav txaus siab rau lwm tsab xov xwm ntawm ntuj tshuaj tiv thaiv kab mob rau dev.
