Primperan yog ib qho tshuaj siv dav hauv tib neeg thiab tsiaj cov tshuaj. Hauv kev muaj tiag, nws yog cov tshuaj tsim los siv rau tib neeg, txawm hais tias tam sim no muaj cov tshuaj analogous uas muaj tib cov khoom xyaw nquag, metoclopramide. Nws ntau yam txheej txheem ntawm kev txiav txim muab qhov sib txawv ntawm cov tshuaj pharmacological, tshwj xeeb yog cov teebmeem antiemetic, prokinetic thiab galactogogue teebmeem.
Yog koj xav paub ntau ntxiv txog primperan rau dev, nws npaum li cas thiab nws siv rau dab tsi, peb xav kom koj koom nrog peb Nyob rau hauv tsab xov xwm nram qab no ntawm peb qhov chaw, qhov twg peb kuj qhia koj txog nws cov kev phiv thiab contraindications.
Primperan yog dab tsi?
Primeran yog lub npe lag luam ntawm cov tshuaj uas nws active ingredient is metoclopramide Hauv kev muaj tiag, primperan yog ib hom tshuaj npaj rau kojsiv nyob rau hauv tib neeg , uas yog muaj nyob rau hauv lub qhov ncauj tshuaj, ntsiav tshuaj thiab tshuaj txhaj. Txawm li cas los xij, muaj cov tshuaj analogous hauv cov kws kho tsiaj uas muaj cov tshuaj metoclopramide ua cov khoom xyaw nquag.
Metoclopramide yog ib yam tshuaj uas nthuav tawm ntau yam kev ua haujlwm, tshwj xeeb:
- Antagonizes dopamine D2 receptors.
- Antagonizes 5-HT3 serotonergic receptors.
- Nws ua raws li tus antagonist ntawm 5-HT4 receptors, uas ua rau nws muaj cholinergic teebmeem ntawm cov leeg du.
Nws cov txheej txheem sib txawv ntawm kev ua haujlwm txhais tau hais tias metoclopramide tsis muaj cov tshuaj pharmacological nkaus xwb, tab sis ob peb. Tshwj xeeb, lub ntsiab lus tseem ceeb no nthuav tawm:
- Antiemetic effect: tswj ntuav.
- Prokinetic effect: ua kom plab hnyuv motility.
- Galactogogue effect: stimulates mis production.
Pimperan siv rau dev dab tsi?
Raws li peb tau hais hauv nqe lus dhau los, primperan yog cov tshuaj uas muaj cov tshuaj antiemetic, prokinetic thiab galactogogue effect, txawm hais tias nyob hauv tshuaj Veterinary tshuaj yog siv los ntawm thawj ob.
Antiemetic nyhuv
Metoclopramide yog lub hauv paus ua haujlwm antiemetic, uas txhais tau hais tias tswj ntuavlos ntawm kev ua ncaj qha rau ntawm ntu ntuav thiab thaj chaw chemoreceptor trigger.
Its antiemetic effect yog siv los tswj ntuav los ntawm:
- Cov txheej txheem digestive.
- Pancreatitis.
- Uraemia: nce ntshav urea ntau ntau).
- kab mob endocrine: xws li Addison tus kab mob los yog hypoadrenocorticism.
- Tshuaj xws li opiates, digitalis, theophylline lossis tshuaj tua kab mob tshuaj tua kab mob.
- ntuav ntawm etiology tsis paub meej.
Thaum ntuav ua rau lub cev qhuav dej ntawm tus tsiaj, ntxiv rau kev siv tshuaj tiv thaiv kab mob xws li metoclopramide, nws yuav tsim nyog los kho koj cov kua thiab electrolyte tshuav.
Prokinetic effect
Metoclopramide ua nyob rau theem ntawm lub plab thiab thawj ntu ntawm cov hnyuv(duodenum thiab jejunum), nyiam lub plab zom mov. Tshwj xeeb tshaj yog, nws nce lub suab thiab amplitude ntawm gastric contractions, txhawb kev so ntawm pylorus (sphincter uas txuas lub plab nrog cov hnyuv me) thiab txhawb nqa peristalsis ntawm txoj hnyuv me.
Its prokinetic effect yog zoo rau kev kho mob ntawm:
- Esophagitis
- Gastroesophageal reflux
- mob plab gastritis
- Pyloric spasm
- Ileus
Pom Primperan for Dogs
koob tshuaj primperan rau dev yog tib yam txawm hais tias nws yog muab tshuaj noj, subcutaneously, los yog intramuscularly.
Tshwj xeeb, koob tshuaj yuav tsum yog 0.5-1 mg ntawm metoclopramide ib kg ntawm qhov hnyav ib hnub. Cov koob tshuaj no yuav tsum muab faib ua 2 lossis 3 txoj kev tswj hwm ib hnub, nyob ntawm seb tus kws kho tsiaj uas sau cov tshuaj pom zoo.
Primeran overdose nyob rau dev
Cases of intoxication by primperan in a dogs are feem ntau yog tshwm sim los ntawm koob tshuaj tsis zoo ntawm cov tshuaj, yog li nws yog ib qho tseem ceeb uas koj yuav tsum xyuas kom meej tias koob tshuaj koj noj yog raws nraim li ib tug kws kho mob tau sau tseg.
Feem ntau cov tsos mob tshwm sim tom qab noj tshuaj ntau dhau yog extrapyramidal phiv (cov tsos mob tshwm sim thaum thaj tsam ntawm lub hlwb lub luag haujlwm ntawm kev sib koom tes, hu ua extrapyramidal system, cuam tshuam). Cov paib no suav nrog:
- Ataxia (incoordination)
- Txoj hauj lwm txawv txav thiab/los yog txav chaw
- Nkauj kho siab
Vim tias tsis muaj cov tshuaj tiv thaiv tshwj xeeb tiv thaiv metoclopramide, qhov kev pom zoo yog muab cov tsiaj nyob ib puag ncig ntsiag to kom txog rau thaum cov cim extrapyramidal ploj mus. Txij li cov tshuaj is sai metabolized and eliminated, cov teebmeem no feem ntau ploj mus sai sai.
Txawm li cas los xij, txoj hauv kev zoo tshaj plaws los tiv thaiv kev noj tshuaj ntau dhau yog keep the drug out of your furry friend's reach thiab, as peb twb tau taw qhia lawm, kom paub tseeb tias koj ua raws li cov tshuaj uas koj tus kws kho tsiaj tau sau tseg.
Primeran Side Effects in Dogs
Raws li primperan SmPC, cov kev phiv cuam tshuam nrog nws cov thawj coj hauv dev tau pom (tsawg dua 1 tus tsiaj rau 10,000). Tsis tas li ntawd, cov kev pom tshwm sim tau hloov pauv thiab ploj mus thaum kho.
Tshwj xeeb, cov kev mob tshwm sim uas tuaj yeem pom nrog kev tswj hwm ntawm primerran hauv dev yog:
- Extrapyramidal signs: xws li agitation, ataxia (incoordination), txawv txav thiab/los yog txav, prostration, tremors, aggressiveness thiab vocalizations.
- Zoo.
- Hypertensive ntsoog hauv dev nrog pheochromocytoma: qog qog adrenal.
Contraindications of Primperan rau dev
Txawm tias qhov tseeb tias primerran yog tshuaj muaj txiaj ntsig zoo , muaj qee qhov xwm txheej pathological uas nws siv tsis zoo. Tshwj xeeb, cov contraindications ntawm primerran rau dev yog raws li nram no:
- Allergy los yog hypersensitivity to metoclopramide los yog rau ib qho ntawm cov excipients uas nrog cov active ingredient.
- Infection or gastrointestinal toxicity: since in these cases antiemetics can limit the expulsion of the infectious or toxic agent.
- Obstruction los yog suspicion gastric or intestinal obstruction: vim lub plab los yog txoj hnyuv yuav tawg. Nrhiav kom paub ntau ntxiv txog kev mob plab hnyuv hauv dev, nws cov tsos mob thiab kev kho mob hauv kab lus no ntawm peb qhov chaw uas peb pom zoo.
- (qaug dab peg) los yog raug mob taub hau.
Txawm hais tias tsis muaj teratogenic lossis tshuaj lom rau tus menyuam hauv plab tau tshwm sim hauv cov tsiaj sim, tsis muaj kev tshawb fawb uas txhawb nqa nws txoj kev nyab xeeb hauv cev xeeb tub lossis lactating bitches. Yog li ntawd, nws raug nquahu kom siv cov tshuaj no nrog ceev faj thaum cev xeeb tub thiab / lossis lactation, yav tas los ua qhov tseeb qhov kev pheej hmoo / txiaj ntsig kev ntsuas.
