Cyclosporine yog ib yam tshuaj immunosuppressiveuas yog siv los kho cov txheej txheem tsis haum thiab cov kab mob tiv thaiv kab mob uas cuam tshuam rau ntau yam kabmob thiab lub cev. Nws yog ib qho tshuaj uas muaj kev ua tau zoo thiab kev nyab xeeb, uas feem ntau cuam tshuam nrog kev mob me me thiab thim rov qab. Txawm li cas los xij, nws tus nqi siab txhais tau hais tias nws tsis yog feem ntau siv los ua cov tshuaj thawj zaug hauv kev kho cov tshuaj tiv thaiv kab mob.
Yog koj xav paub ntau ntxiv txog cyclosporine rau dev, tsis txhob nco cov lus hauv qab no ntawm peb qhov chaw uas peb tham txog nws noj, siv thiab phiv.
Cyclosporine yog dab tsi?
Cyclosporine, tseem hu ua cyclosporine A, yog cov tshuaj tiv thaiv kab mob, uas yog, tshuaj siv los txo cov lus teb ntawm lub cev tiv thaiv kab mob. Tshwj xeeb, nws yog ib qho tshuaj tiv thaiv kab mob uas ua tshwj xeeb thiab thim rov qab ntawm T lymphocytes
Nov yog ib yam tshuaj muaj txiaj ntsig zoo thiab muaj kev nyab xeeb rau kev siv hauv cov dev, txawm hais tias nws muaj tus nqi pheej yig duadua lwm cov tshuaj tiv thaiv kab mob, xws li raws li corticosteroids.
Tam sim no, nws muaj nyob rau hauv kev ua lag luam nyob rau hauv peb yam kev nthuav qhia:
- Soft capsules rau kev tswj qhov ncauj
- Oral solution
- Ophthalmic ointment
Cyclosporine siv rau dev dab tsi?
Raws li peb tau piav qhia, cyclosporine yog cov tshuaj tiv thaiv kab mob muaj zog. Nws ua hauj lwm los ntawm kev khi rau T lymphocytes thiab inhibiting zus tau tej cov interleukin-2 (IL-2) thiab lwm yam cytokines koom nyob rau hauv activating lub cev. Vim li no, cyclosporine yog siv los ua kev tiv thaiv kab mob hauv cov kab mob uas xav tau kev hloov pauv ntawm kev ua haujlwm ntawm lub cev tiv thaiv kab mob, xws li cov txheej txheem tsis haum thiab cov kab mob tiv thaiv kab mobHauv seem tom ntej no, peb yuav tham ntxiv txog kev siv cyclosporine hauv dev.
Txawm hais tias muaj kev ua tau zoo thiab kev nyab xeeb ntawm cyclosporine, nws tsis yog feem ntau yog ib qho tshuaj ntawm cov kev xaiv thawj zaug hauv kev tiv thaiv kab mob vim nws cov nqi siab. Hauv nruab nrab-loj dev, kev kho mob nrog cyclosporine tuaj yeem nyob nruab nrab ntawm € 180 thiab € 600 ib hlis (nyob ntawm qhov koob tshuaj), uas txhais tau hais tias ntau tus neeg zov me nyuam tsis tuaj yeem them tus nqi kho mob. Vim li no, cyclosporine feem ntau siv hauv cov neeg mob uas tsis kam los yog teb rau lwm cov tshuaj tiv thaiv kab mob pheej yig dua, xws li corticosteroids..
Siv cyclosporine rau dev
Raws li peb tau taw qhia hauv ntu dhau los, cyclosporine yog siv los kho cov kab mob uas yuav tsum tau siv tshuaj tiv thaiv kab mob. Tshwj xeeb, cyclosporine hauv dev yog siv rau hauv:
- Allergic processes: nws yog tshwj xeeb tshaj yog qhia los kho mob atopic dermatitis nyob rau dev.
- Immune-mediated diseases: pawg no suav nrog cov kab mob sib txawv heev uas cuam tshuam rau ntau yam khoom siv thiab tshuab. Qee qhov nquag tshaj plaws yog: kev tiv thaiv kab mob hemolytic anemia, kab mob plab hnyuv (los yog IBD), perianal fistulae, tiv thaiv kab mob stomatitis, tiv thaiv kab mob siab kab mob, tiv thaiv kab mob meningoencephalitis, lupus erythematosus, immune-mediated conjunctiv, thiab. uveitis.
Dog Cyclosporine Dosage
koob tshuaj cyclosporine hauv dev nyob ntawm ntau yam:
- Txoj kev tswj hwm.
- Pathology los kho thiab nws qhov hnyav.
- Patient Response.
Dog Oral Cyclosporine Dosage
Cov koob tshuaj pom zoo ntawm cyclosporine noj los ntawm lub qhov ncauj (ob qho tib si capsules thiab qhov ncauj tshuaj) yog 5 mg/kg ntawm lub cev hnyav. Nws yuav tsum tau muab tsawg kawg 2 teev ua ntej lossis tom qab noj mov.
Tshwj xeeb, kev noj tshuaj ntawm qhov ncauj cyclosporine yog raws li hauv qab no:
- , kev kho mob yuav tsum yog noj txhua hnub mus txog rau qhov chaw kho mob. ntawm tus tsiaj raug kuaj pom, uas feem ntau tshwm sim hauv 4 lub lis piam. Yog tias tom qab 8 lub lis piam tsis pom kev txhim kho, kev kho mob yuav tsum tau txiav.
- raws li kev noj tshuaj. Nyob rau lub sijhawm no, tus kws kho tsiaj yuav tsum kuaj xyuas thiab kho cov koob tshuaj raws li kev soj ntsuam cov lus teb.
- Thaum cov tsos mob tswj tau, tus kws kho tsiaj yuav muab tshuaj kho txhua 3 lossis 4 hnub.
- Thaum tus kab mob no tswj tau, koj muaj peev xwm stop treatment. Yog tias cov tsos mob tshwm sim dua, kev kho mob tuaj yeem rov pib dua nrog ib koob tshuaj txhua hnub.
Dog Ophthalmic Cyclosporine Dosage
Ua ntej siv cov tshuaj pleev ophthalmic, lub qhov muag yuav tsum tau muab ntxuav kom huv ntawm cov av thiab exudates siv cov tshuaj uas tsis ua rau khaus. Tom qab ntawd, siv 1 cm ntawm cov tshuaj pleev rau qhov muag raug mob thiab rov ua daim ntawv thov txhua 12 teev.
Lub sijhawm ntawm kev kho mob nrog cyclosporine ophthalmic ointment nyob ntawm qhov hnyav ntawm cov txheej txheem thiab cov lus teb tau txais.
Cyclosporine phiv rau dev
Cyclosporine yog ib yam tshuaj muaj kev nyab xeeb Qhov tseeb, nws cov ntaub ntawv qhia tau hais tias cov kev phiv tshwm sim feem ntau yog mob me me thiab tsis tshua muaj tshwm sim, tsawg zaus. Tsis tas li ntawd, lawv feem ntau tsis tas yuav tsum tau txiav kev kho mob ntxiv thiab feem ntau rov qab ua dua tom qab ua tiav kev kho.
Txawm li cas los xij, zoo li txhua yam tshuaj, cyclosporine tsis raug zam los ntawm kev phiv. Cov kev tsis zoo tshwm sim feem ntau cuam tshuam nrog nws cov thawj coj yog:
- Pab mob plab: anorexia, ntuav, mucous los yog quav quav thiab raws plab.
- Gingival hyperplasia: Feem ntau cov dev kho nrog cyclosporine tsim kev loj hlob ntawm cov pos hniav. Txawm li cas los xij, feem ntau lawv tsis muaj teeb meem thiab ploj thaum kho.
- Hypertrichosis: plaub hau loj hlob heev.
- Diabetes mellitus: Nws tau raug pom tsis tshua muaj, feem ntau cuam tshuam nrog sab hnub poob highland terrier yug.
- Eye redness, blepharospasm (qhov muag kaw vim mob qhov muag), conjunctivitis thiab khaus qhov muag.
Contraindications ntawm cyclosporine rau dev
Txawm hais tias muaj kev ua tau zoo thiab kev nyab xeeb ntawm cyclosporine, muaj qee qhov xwm txheej uas nws siv yuav cuam tshuam. Tom ntej no, peb hais txog lub ntsiab contraindications ntawm cyclosporine hauv dev:
- Allergy to cyclosporine los yog ib qho ntawm cov tshuaj excipients.
- Puppies tsawg dua 6 lub hlis laus los yog hnyav dua 2 kg.
- Dog nrog keeb kwm kho mob malignant qog.
- Vaccination: Tsis muaj tshuaj tiv thaiv (txawm muaj sia lossis tsis muaj zog) yuav tsum tau txhaj tshuaj thaum kho lossis ob lub lis piam ua ntej lossis tom qab kho, raws li cov Cov tshuaj yuav cuam tshuam rau qhov ua tau zoo ntawm kev txhaj tshuaj.
Cyclosporine hla cov placental barrier thiab tawm hauv cov mis nyuj. Yog li ntawd, kev siv cov tshuaj no tsis pom zoo nyob rau hauv cev xeeb tub los yog lactating bitches Txawm li cas los xij, thaum xav tias tsim nyog, kev kho mob nrog cyclosporine yuav pib rau hauv cov me nyuam mos tom qab muaj kev pheej hmoo zoo. /kev ntsuam xyuas los ntawm kws kho tsiaj.
Cyclosporine overdose los yog intoxication hauv dev
Cyclosporine overdose lossis intoxication hauv dev tuaj yeem tshwm sim los ntawm kev noj tshuaj tsis raug lossis los ntawm kev tswj hwm los ntawm cov neeg ua haujlwm yuam kev. Txawm hais tias cov kev phiv tsis zoo cuam tshuam nrog kev siv tshuaj ntau dhau tsis loj heev, nws yog ib qho tseem ceeb kom kuaj xyuas lawv raws sijhawm thiab mus ntsib kws kho tsiaj txhawm rau tsim kev kho kom tsim nyog tshaj plaws.
Tshwj xeeb, cov tshuaj tiv thaiv uas tuaj yeem pom thaum muaj kev qaug cawv vim koob tshuaj 4 zaug ntau dua li cov tshuaj pom zoo lossis vim kev noj ntau dhau rau 3 lub hlis yog:
- Hyperkeratosis in the auricle.
- Pooblos yog poob phaus.
- Hypertrichosis: plaub hau loj hlob heev.
ZAU AG
Thaum twg koj pom cov tsos mob no, tsis txhob yig mus cuag koj tus kws kho tsiaj uas ntseeg siab. Txawm hais tias tsis muaj cov tshuaj tiv thaiv tshwj xeeb rau cyclosporine, kev kho mob tuaj yeem tsim los tswj cov cim qhia ntawm cyclosporine intoxication hauv dev. Cov tsos mob feem ntau yog thim rov qab li ntawm 2 lub hlis.
Txawm li cas los xij, nco ntsoov qhov tseem ceeb ntawm kev khaws cov tshuaj kom deb ntawm koj cov tsiaj thiab ua tib zoo ua raws li cov lus qhia los ntawm koj tus kws kho tsiaj. Qhov no yuav yog txoj hauv kev yooj yim tshaj plaws kom tsis txhob muaj mob ntau dhau los yog qaug cawv los ntawm cyclosporine.
