Ranitidine yog ib yam tshuaj uas inhibits gastric acid secretion nyob rau hauv miv vim nws khi rau cov histamine H2 receptors nyob rau hauv lub plab, lub luag hauj lwm rau tso tawm hais tias acid. Vim li no, nws yog ib qho active ingredient siv nyob rau hauv cov txheej txheem muaj feem xyuam rau lub plab acids, xws li gastritis, esophagitis, gastroesophageal reflux thiab gastric ulcers. Tsis tas li ntawd xwb, ranitidine kuj muaj cov teebmeem prokinetic, yog li nws txhawb kev zom zaub mov thiab muaj kev tiv thaiv ntawm lub plab hnyuv mucosa, uas yog qhov tseem ceeb thaum siv qee yam tshuaj.
ranitidine yog dab tsi?
Ranitidine yog ib yam khoom siv lossis tshuaj uas belongs rau pawg ntawm H2 antagonists H2 receptors yog ib qho ntawm ob hom histamine receptors. Histamine yog, tsis muaj qhov tsis ntseeg, qhov loj tshaj plaws paracrine stimulant ntawm gastric acids, tso cov kua qaub tom qab khi rau H2 receptors. Histamine muaj nyob rau hauv mast hlwb ntawm lub plab thiab tso tawm los ntawm qhov kev txiav txim ntawm gastrin. Nyob rau hauv txoj kev no, ranitidine khi rau H2 receptors thiab tiv thaiv kev khi ntawm histamine, limiting gastric acid secretion
Vim nws ua rau txo qis hauv plab acids, tiv thaiv thiab kho peptidic ulcers, gastroesophageal reflux, o ntawm txoj hlab pas los yog esophagitis thiab o ntawm lub plab los yog gastritis nyob rau hauv miv. Tsis tas li ntawd, ranitidine tuaj yeem ua kom lub plab zom movvim nws cov nyhuv inhibitory ntawm acetylcholinesterase, uas ua rau muaj kev nce hauv acetylcholine thiab muaj kev tiv thaiv thiab kho cov nyhuv. lub plab hnyuv mucosa, ua kev tiv thaiv los ntawm kev ua xua ntawm cov tshuaj uas tsis yog-steroidal anti-inflammatory tshuaj (NSAIDs).
Ranitidine khi tsis zoo rau cov ntshav plasma protein, hla cov ntshav-hlwb barrier lossis ntshav-hlwb barrier, pom nyob rau hauv cov qib zoo hauv cov kua cerebrospinal thiab kuj kis mus rau hauv cov kua mis. Cov nyhuv ntawm inhibition ntawm lub plab secretion kav ntev li ib teev, yog li yuav tsum tau noj txhua hnub, metabolism hauv siab thiab tshem tawm yog lub raum.
Dab tsi yog ranitidine siv rau miv?
Raws li tau tham, ranitidine yog siv rau gastritis, esophagitis, thiab ua kom plab hnyuv txav ntawm cov zaub movhauv miv vim nws muaj peev xwm thaiv histamine nyob rau hauv lub plab, qhov tseem ceeb nyob rau hauv secretion ntawm gastric acid, qhov no yog lub luag hauj lwm rau cov tsos ntawm cov pathologies nyob rau hauv cov tsiaj.
Vim ranitidine thaiv kev tso tawm ntawm cov tshuaj histamine hauv lub plab thiab inhibits cov kua qaub hauv plab, nws txo qhov muaj peev xwm ua rau lub plab los ntawm kev ua rau ib puag ncig hauv plab ntau alkaline.
Lwm yam kev siv ranitidine hauv miv yog kho xeev siab uas tshwm sim hauv miv tom qab siv qee yam tshuaj, intoxications, kua qaub ntau dhau. los yog kev txom nyem los ntawm cov kab mob ntev xws li kab mob raum, mob siab, mob qog noj ntshav, mob pancreatitis thiab mob plab plob tsis so tswj. Cov cim qhia tias tus miv xeev siab yog di ncauj smacking, anorexia, tsis kam noj zaub mov, poob dej, ntuav, thiab nqos tas li.
Kos Ranitidine rau miv
koob tshuaj ranitidine hauv miv yog 2 mus rau 4 mg ib kg ntawm lub cev hnyav ib hnub twgKev tswj yuav ua tau ntawm qhov ncauj, parenteral los yog txhaj tshuaj. Nyob ntawm daim ntawv ntawm cov tshuaj, qhov hnyav ntawm tus miv thiab qhov concentration ntawm ranitidine hauv cov khoom, qhov ntau npaum li cas yuav txawv.
Tsis txhob muab ranitidine rau koj tus miv yam tsis tau muaj cov kws kho tsiaj cov lus qhia thiab tshuaj thawj zaug, tsuas yog tus kws tshaj lij no yog tus uas tuaj yeem txhais cov koob tshuaj zoo tshaj plaws rau koj tus miv raws li qhov nws muaj thiab nws cov kev xav tau. Nco ntsoov tias nws yuav siv li ob peb hnub kom pom cov txiaj ntsig ntawm kev txhim kho cov tsos mob xws li xeev siab, reflux thiab anorexia.
Side Effects of Ranitidine for Cats
Ranitidine feem ntau tsis ua rau muaj kev phiv hauv miv. Txawm li cas los xij, nws yuav tsum raug sau tseg tias qee qhov tsis xav tau tshwm sim nrog kev kho mob ranitidine, xws li cov hauv qab no:
- Rebound effect nrog hypersecretion of gastric acid tom qab tshem tawm ntawm kev kho mob ranitidine.
- Drug accumulation hauv cov neeg mob raum lossis mob siab.
-NOJ NOJ NOJ DAG
Contraindications of ranitidine rau miv
Nws yuav tsum raug coj mus rau hauv tus account tias nyob rau hauv cov ntaub ntawv ntawm overdose ntawm ranitidine, ib tug nce nyob rau hauv hepatic ALT (alanine aminotransferase enzyme) yuav raug pom. Tsis tas li ntawd, ranitidine muaj ib tug xov tooj ntawm contraindications nyob rau hauv miv.
pib nrog, ranitidine yuav tsum tsis txhob siv yog tias tus miv nyob rau kho nrog itraconazole or ketoconazolevim tias cov tshuaj no xav tau ib puag ncig acidic rau lawv qhov ncauj nqus vim lawv tsis muaj zog hauv paus, yog li kev kho nrog ranitidine txo cov nyhuv ntawm cov tshuaj no los ntawm kev txo lawv cov bioavailability. Nyob rau hauv rooj plaub uas yuav tsum tau muaj kev kho mob antifungal nrog kev siv ranitidine, nws yog qhov zoo dua los xaiv, yog tias ua tau, rau lwm cov tshuaj tiv thaiv kab mob xws li fluconazole, nws qhov nqus tsis nyob ntawm pH ntawm lub plab. Nws kuj yuav tsum tsis txhob siv nrog qee qhov ncauj cephalosporins vim ranitidine tuaj yeem cuam tshuam rau lawv cov tshuaj pharmacokinetics.
Ranitidine yuav tsum tsis txhob siv rau hauv poj niam cev xeeb tub nyob rau hnub kawg ntawm cev xeeb tub thiab tsis tau qhia hauv cav yog kab mob siab los yog raum , yuav tsum tau siv koob tshuaj qis dua. Hauv poj niam lactating ranitidine yuav tsum tsis txhob siv, vim nws nkag mus rau hauv cov mis nyuj thiab kittens tseem tuaj yeem ua rau lawv lub plab tso rau tib lub sijhawm uas cov tsos mob tshwm sim vim yog stimulation ntawm lub hauv paus paj hlwb thiab inhibit cov metabolism ntawm lwm yam tshuaj.
Cev faj siv ranitidine hauv miv
Nws yuav tsum tau muab sau tseg tias, thaum pib lub Ob Hlis 2022, lub Spanish Agency for Medicines and He alth Products (AEMPS) [1] tau tsim cov lus pom zoo ntawm tsis txhob siv cov tshuaj magisterial uas muaj ranitidine lossis tshuaj ranitidine hauv txhua yam tshuaj vim muaj kev pheej hmoo ntawm kev nthuav tawm cov impurity N-Nitrosodimethylamine (NDMA), tseem hu ua nitrosamine, nyob rau theem siab tshaj cov uas tau tsim, yog ib tug muaj peev xwm carcinogen.
Qhov no tau pom nyob rau hauv 2019, tso cai rau nws siv nyob rau hauv daim ntawv ntawm kev txhaj tshuaj raws li nws yog tib H2 inhibitor ua lag luam nyob rau hauv daim ntawv no ntawm kev nthuav qhia, thiab tau qhia rau ib co kev kho mob xav tau kev pab nyob rau hauv cov neeg mob thaum batches. kuaj xyuas qhov sib xyaw no. Xyoo tom ntej, los ntawm kev txiav txim siab ntawm Pawg Neeg Saib Xyuas, tag nrho cov ntawv tso cai hauv lub tebchaws rau cov khoom siv hauv qhov ncauj tau raug tshem tawm hauv Spain vim tau pom qhov sib xyaw no nyob rau theem siab dua cov uas tau tsim nyob rau hauv cov khoom sib txawv ntawm cov khoom muaj txiaj ntsig, tab sis tsis yog li ntawd nrog rau cov kev siv cov hlab ntsha, tuaj yeem ncua nws qhov kev ncua mus txog lub Kaum Ib Hlis 25, 2021. Txawm li cas los xij, thaum hnub no los txog, tsis muaj dab tsi tuaj yeem tiv thaiv nws qhov kev ncua, yog li niaj hnub no tsis muaj tshuaj nrog ranitidine yuav tsum tau muab tshuaj rau qhov ncauj lossis parenteral hauv tib neeg cov tshuaj lossis hauv tshuaj kho tsiaj., lwm yam H2 receptor inhibitors xws li famotidine lossis cimetidine yuav tsum tau siv.
