Selegiline yog hom B monoamine oxidase inhibitor siv hauv tib neeg cov tshuaj rau kev kho mob Parkinson's disease. Txawm li cas los xij, nws yog ib qho tshuaj uas tau tso cai siv rau hauv cov tshuaj kho tsiaj. Tshwj xeeb, nws yog siv rau kev kho mob ntawm kev txawj ntse tsis ua haujlwm nyob rau hauv cov dev geriatric, vim tias nws tau pom tias yuav txhim kho lub sij hawm luv luv, txo cov tsos mob ntawm kev paub tsis meej thiab ua kom lub neej ntev hauv cov dev nrog cov kab mob no.
Yog koj xav paub ntau ntxiv txog selegiline in dogs, koom nrog peb hauv tshooj tom ntej ntawm peb qhov chaw peb yuav tham txog dose, use and side effects ntawm cov tshuaj no.
selegiline rau dev yog dab tsi?
Selegiline yog ib yam tshuaj uas muaj nyob hauv pawg inhibitors ntawm enzyme monoamine oxidase hom B (MAO-B), uas muaj cov hauv qab no. teebmeem:
- Los ntawm kev xaiv inhibiting lub enzyme MAO-B hauv lub hlwb, nws tswj kom nce qib ntawm dopamine thiab lwm yam catecholamines hauv cerebral. cortex thiab hippocampus, uas tsis txaus rau cov neeg mob dementia.
- Hais me ntsis antidepressant effect.
- Suppresses cov oxidative nyhuv txuam nrog dopamine thiab txo cov load ntawm dawb radicals, uas muab ib tug neuroprotective nyhuv.
Tam sim no, tsuas yog selegiline tab tom ua lag luam raws li cov ntsiav tshuaj siv rau tib neeg Txawm li cas los xij, cov kws kho tsiaj kuj tuaj yeem sau cov tshuaj no siv lub npe hu ua "cascade prescription", uas muaj cov tshuaj uas tsis tau tso cai rau ib hom tsiaj tshwj xeeb thaum muaj qhov sib txawv ntawm kev kho mob.
Selegiline siv rau dev dab tsi?
Selegiline yog siv rau kho mob ntawm kev paub tsis meej dysfunction syndrome nyob rau hauv cov dev geriatricCognitive dysfunction syndrome (SCD) yog ib tug kab mob degenerative zoo ib yam li Alzheimer's. kab mob hauv tib neeg, uas cuam tshuam rau cov dev geriatric thiab ua rau muaj ntau yam kev coj cwj pwm tsis zoo. Txawm hais tias qhov tseeb mechanism uas selegiline induces kev txhim kho nyob rau hauv cov dev nrog CDS tsis yog tag nrho to taub, nws ntseeg tau hais tias yog vim muaj kev nce hauv dopamine thiab lwm yam catecholamines nyob rau hauv cerebral cortex thiab hippocampus.
Nws yuav tsum tau hais tias kev siv selegiline tau kawm nyob rau hauv kev kho mob ntawm canine cushing's syndrome ntawm pituitary keeb kwm. Selegiline ua rau nce qib hauv dopamine, uas muaj peev xwm inhibiting exacerbated zus tau tej cov ACTH uas tshwm sim thaum pituitary cushing. Cov txiaj ntsig ntawm cov kev tshawb fawb no cuam tshuam kev siv selegiline tsuas yog kev kho mob rau pituitary cushing vim nws qhov ua tau zoo. Txawm li cas los xij, nws yuav raug nquahu kom siv selegiline ua ke nrog lwm cov tshuaj (xws li trilostane) vim nws zoo nkaus li txhim kho qib kev ua haujlwm thiab lub neej zoo hauv cov dev uas muaj kab mob pituitary cushing.
Hauv lwm tsab xov xwm no peb tham tob txog cov tsos mob thiab kev kho mob ntawm Cushing's syndrome hauv dev.
Dose of selegiline in dogs
koob tshuaj 0.5 mg per kg ntawm qhov hnyav ib hnub tau pom tias muaj txiaj ntsig zoo hauv kev txhim kho lub sijhawm luv luv, txo cov tsos mob ntawm kev paub tsis meej thiab ua kom lub neej ntev nyob rau hauv cov dev laus nrog kev paub tsis meej dysfunction syndrome. Ib yam li ntawd, kev tswj hwm ntawm selegiline raug pom zoo rau cov dev thaum sawv ntxov, tshwj xeeb tshaj yog nyob rau hauv cov dev uas muaj kev txawj ntse tsis ua haujlwm uas muaj kev hloov pauv hauv lub voj voog pw tsaug zog / tsaug zog.
Cov lus teb rau kev kho tej zaum yuav tshwm sim nyob rau hauv ob peb hnub, txawm hais tias feem ntau cov neeg zov me nyuam pom kev txhim kho nyob rau hauv thawj ob lub lis piam ntawm kev kho mob.
Selegiline Cov Teeb Meem Hauv Dogs
Ntawm qhov koob tshuaj pom zoo, cov kev mob tshwm sim tau raug tshaj tawm hauv cov neeg mob tsawgTxawm li cas los xij, ib yam li kev kho tshuaj kho mob, Nws Nws yog ib qho tseem ceeb uas yuav tau mus koom nrog qhov tshwm sim ntawm qhov tshwm sim tsis zoo thiab mus ntsib kws kho tsiaj yog tias lawv tshwm sim.
Hauv cov xwm txheej tshwj xeeb ntawm selegiline hauv dev, cov kev mob tshwm sim tuaj yeem pom tau yog:
- Sedation or excitement, nyob ntawm tus neeg mob.
- Serotonergic Syndrome: inhibition ntawm enzyme monoamine oxidase tiv thaiv cov metabolism ntawm ntau cov enzymes tam sim no hauv cov zaub mov, uas tuaj yeem ua rau serotonin receptors. thiab tsim cov kab mob no, tus cwj pwm los ntawm hyperthermia, nqaij tawv, tshee, cov tsos mob plab, thiab lwm yam.
Contraindications ntawm selegiline nyob rau hauv dev
Txawm tias selegiline yog ib yam tshuaj uas muaj ntawv tso cai rau kev siv kws kho tsiaj, muaj qee qhov xwm txheej uas nws siv tuaj yeem cuam tshuam. Tom ntej no, peb sau lub ntsiab contraindications ntawm selegiline nyob rau hauv dev:
- Allergy los yog hypersensitivity rau selegiline los yog rau ib qho ntawm cov excipients uas nrog cov khoom xyaw nquag
- Dog raug kho nrog tricyclic antidepressants, serotonin reuptake inhibitors (xws li fluoxetine), serotonin reuptake inhibitors, thiab norepinephrine (xws li venlafaxine), sympathomimetics, monoamine oxidase inhibitors, thiab/los yog opioids.
Rau tag nrho cov lus saum toj no, nws yog ib qho tseem ceeb heev rau kev tswj hwm selegiline hauv cov dev raws li kws kho tsiaj saib xyuas, peb yuav tsum tsis txhob muab tshuaj rau peb tus kheej vim tias peb tuaj yeem ua rau nws qhov xwm txheej tsis zoo.
