Theophylline yog ib qho alkaloid ntawm tsev neeg methylxanthine, uas yog siv rau kev kho mob ntawm cov kab mob ua pa sib txawv hauv cov dev vim nws cov nyhuv bronchodilator. Txawm hais tias nws yog ib qho tshuaj zoo, nws tsim cov lus teb sib txawv heev hauv cov neeg mob, uas ua rau nws tsim nyog los tswj cov koob tshuaj ntawm txhua tus tsiaj thiab saib xyuas cov qib plasma ntawm cov tshuaj. Tsis tas li ntawd, thaum kho, cov tsos mob tshwm sim uas yuav tsum tau hloov kho koob tshuaj lossis txiav kev kho mob yuav tsum tau saib xyuas.
Yog koj xav paub ntxiv txog theophylline rau dev, nws npaum li cas, siv thiab phiv koom nrog peb hauv tsab xov xwm no ntawm peb lub xaib ntawm qhov peb kuj piav qhia tias nws cov contraindications yog dab tsi.
theophylline yog dab tsi?
Theophylline yog ib qho alkaloid ntawm tsev neeg methylxanthine uas feem ntau siv hauv tshuaj kho tsiaj rau
Caffeine yog ib qho kev paub dav dav uas tseem nyob hauv tsev neeg methylxanthine. Yog li ntawd, peb tuaj yeem txiav txim siab tias peb tab tom cuam tshuam nrog tsev neeg central nervous system stimulant tshuaj Methylxanthines yog cov tshuaj uas ua rau lub cev purinergic, uas yog txuam nrog. central thiab peripheral paj hlwb. Tshwj xeeb, lawv ua thaiv cov kab mob purinergic, uas ua rau muaj kev cuam tshuam rau lub paj hlwb.
Tsis txhob yig tau sab laj nrog lwm tsab xov xwm txog kab mob ua pa hauv dev.
theophylline rau dev yog dab tsi?
Theophylline yog ib yam tshuaj uas ua rau muaj kev cuam tshuam hauv ntau thaj chaw organic. Ntawm lwm yam, stimulates lub paj hlwb, muaj diuretic action,vasodilator effect los yog vasoconstrictor thiab inotropic effect at cardiac level
Txawm li cas los xij, hauv dev nws yog siv los kho cov kab mob uas cuam tshuam rau txoj kev ua pa vim nws bronchial action, muab hais tias:
- Ua bronchodilation: los ntawm kev so ntawm cov leeg bronchial.
- Inhibits tso tawm bronchoconstrictor mediators.
- Nyob mucociliary clearance.
- Prevents diaphragmatic fatigue.
- Ntxiv rau, nws tso cai rau koj txo cov koob tshuaj corticosteroids.
Tshwj xeeb, theophylline yog siv rau hauv cov dev rau kho cov kab mob tracheobronchial xws li tracheal collapse, chronic bronchitis lossis Chronic obstructive pulmonary disease.
Nws yuav tsum tau muab sau tseg tias, txawm hais tias theophylline yog ib qho tshuaj siv los kho qee yam kab mob ua pa hauv cov dev, nws is tam sim no tsis tau muag hauv Spaintsis muaj tshuaj veterinary uas muaj theophylline siv rau cov tsiaj me.
Yog li no, thaum koj tus kws kho tsiaj txiav txim siab pib kho cov tshuaj no, koj yuav tsum siv cov tshuaj cascade: uas muaj nyob rau hauv daim ntawv tshuaj. ib qho tshuaj uas tsis tso cai rau ib hom tsiaj tshwj xeeb thaum muaj qhov sib txawv ntawm kev kho mob. Qhov ncauj los yog parenteral formulations uas yog marketed rau siv nyob rau hauv tib neeg yog feem ntau raug sau tseg.
Tsis txhob yig tau nyeem lwm cov ntawv no ntawm peb qhov chaw hais txog Tracheal Collapse hauv dev, Cov tsos mob thiab kev kho mob thiab mob ntsws ntsws hauv dev, cov tsos mob thiab kev kho mob.
Theophylline Dosage for Dogs
Ib qho ntawm cov laj thawj vim li cas theophylline feem ntau tsis siv los ua kev kho mob ntawm thawj qhov kev xaiv yog qhov hloov pauv loj heev hauv cov lus teb ntawm cov neeg mob, uas ua rau nws tsim nyog rau hauv txhua tus tsiajthiab saib xyuas cov qib plasma ntawm cov tshuaj.
Raws li kev qhia, koob tshuaj zoo raug txiav txim siab hauv dev:
- Orally: 10 mg ib kg ntawm qhov hnyav txhua 12 teev (txawm tias lawv tuaj yeem sib txawv ntawm 7, 5-30 mg rau ib kg qhov hnyav. txhua 12 teev
- Intravenous or intramuscular route: 4-8 mg per kg ntawm qhov hnyav.
Txawm li cas los xij, thaum pib kev kho mob, nws yog ib qho tseem ceeb uas yuav tsum tau saib xyuas cov qib plasma ntawm cov tshuaj kom hloov cov koob tshuaj rau txhua tus neeg mob raws li qhov tshwm sim thiab qhov tshwm sim ntawm qhov tshwm sim tsis zoo.
Theophylline Overdose in aub
Theophylline overdoses nyob rau hauv dev tuaj yeem tshwm sim los ntawm dosing errors ntawm cov tshuaj los yog accidental loj heev noj, uas yog feem ntau ua rau.
Theophylline overdose yuav ua rau muaj ntau yam kev phiv xws li:
- VimYog tias koj xav paub ntau ntxiv txog ntuav hauv dev: nws ua rau thiab kev kho mob, nyeem kab lus no uas peb pom zoo.
- Koj tseem tuaj yeem saib cov kab lus no ntawm peb qhov chaw hais txog Kev qaug dab peg hauv dev: lawv qhov laj thawj, kev kho mob thiab yuav ua li cas.
. Mus saib cov ntawv no los ntawm peb lub vev xaib txog 5 cov tsos mob ntawm cov kab mob plawv hauv cov dev, ntawm no.
1. TREMORS Vim li cas kuv tus dev tshee hnyo thiab taug kev tsis tau? Nrhiav cov lus teb hauv kab lus hauv qab no.
Yog li ntawd, thaum kuaj pom muaj tshuaj lom theophylline, koj yuav tsum mus rau chav xwm txheej ceev mus rau chaw kho tsiaj kom tsis txhob nqus cov tshuaj. tshuaj kom deb li deb tau (los ntawm kev ua kom ntuav, ua rau plab hnyuv, lossis siv cov tshuaj tua kab mob los yog cov tshuaj laxative) thiab kho cov cim qhia txog kev qaug cawv.
Txawm li cas los xij, nco ntsoov qhov tseem ceeb ntawm kev khaws txhua yam tshuaj kho mob kom deb ntawm koj cov tsiaj, vim nws yuav yog txoj hauv kev zoo tshaj plaws zam txim los ntawm kev noj tshuaj tsis haum.
Theophylline Cov Kev Mob Phem Hauv Cov dev
Txawm tias yog ib qho tshuaj uas muaj ntau yam txiaj ntsig, theophylline tuaj yeem ua rau muaj kev phiv ntau yam, tshwj xeeb tshaj yog thaum noj tshuaj ntau. Cov kev tsis zoo tseem ceeb cuam tshuam nrog kev siv theophylline yog:
- Generalized stimulation of the central nervous system: thaum noj ntau heev nws tuaj yeem ua rau poob siab, tshee, hyperesthesia, nqaij contractions, hyperexcitability thiab suav nrog tonic-clonic qaug dab peg. Tej zaum tsab xov xwm no hais txog Cramps hauv dev: lawv qhov ua rau, cov tsos mob thiab yuav ua li cas thiaj txaus siab rau koj.
- : ntuav (vim nws ua rau lub chaw ntuav) thiab raws plab. Txhob ua siab deb saib zaj no hais txog Hom mob raws plab hauv dev.
- Cardiac disorders: sinus or ventricular tachycardia, extrasystoles or ventricular arrhythmia.
- Vascular Disorders: vasodilation and hypotension.
Thaum ib qho ntawm cov kev phiv tshwm sim tshwm sim, lub plasma concentration ntawm theophylline yuav tsum tau soj ntsuam los kho cov koob tshuaj. Thaum mob hnyav, kev tswj hwm tshuaj yuav tsum raug txiav tawm.
Contraindications of theophylline rau dev
Ua ntej pib kho theophylline hauv dev, nws yog ib qho tseem ceeb uas yuav tau xav txog cov xwm txheej uas kev tswj hwm ntawm cov tshuaj no yog contraindicated:
- Allergy or hypersensitivity to the active ingredient rau lwm cov methylxanthines.
- Allergy or intolerance to the excipients ntawm cov tshuaj: sucrose, lactose, starch, etc.
- Kho nrog: enrofloxacin, clindamycin, cimetidine, allopurinol, lincomycin thiab/los yog β-blockers, txij li thaum theophylline tsim tshuaj cuam tshuam nrog cov tshuaj no.. Cov neeg mob uas xav tau kev kho mob ua ke nrog theophylline thiab ib qho ntawm cov tshuaj no yuav tsum tau saib xyuas kom tsis txhob muaj kev noj ntau dhau.
