Medullary aplasia is a bone marrow disease uas tuaj yeem cuam tshuam rau dev. Nws muaj qhov tsis txaus ntawm tag nrho lossis qee qhov ua ntej ntawm cov kab ntawm cov qe ntshav dawb, cov qe ntshav liab thiab platelets, yog li cov tsos mob uas tus dev yuav tshwm sim yuav txawv nyob ntawm seb qhov tsis muaj dab tsi. Piv txwv li, yog tias koj tsis muaj cov qe ntshav liab koj yuav muaj ntshav liab. Yog tias nws yog cov qe ntshav dawb, koj yuav kis tau, thiab yog tias nws tsis muaj platelets, koj yuav los ntshav.
Lub hauv paus chiv keeb ntawm canine pob txha aplasia tuaj yeem muaj ntau haiv neeg thiab suav nrog txhua yam los ntawm kev kis mus rau tshuaj, tshuaj lom lossis kab mob. Kev kuaj mob yog qhov yooj yim, tab sis kev kho mob nyuaj, ua rau qhov kev mob tshwm sim ntawm tus kab mob yuav suav tias yog tshwj tseg lossis tsis zoo rau feem ntau.
Cia nyeem tsab xov xwm no rau ntawm peb lub xaib kom paub txog bone marrow aplasia hauv dev, nws cov tsos mob thiab kev kho mob.
pob txha pob txha aplasia yog dab tsi?
Medullary aplasia los yog pob txha pob txha aplasia hu ua hypoplasia ntawm erythroid, myeloid thiab megakaryocytic kab, precursors ntawm cov qe ntshav uas pib hauv lub pob txha. Vim li no, muaj qhov txo qis ntawm cov qe ntshav liab lossis erythrocytes, cov qe ntshav dawb lossis leukocytes lossis platelets hauv cov ntshav peripheral. Cov pob txha pob txha aplasia yog tag nrho yog tias tag nrho cov precursors raug cuam tshuam los yog ib feem yog tias tsuas yog qee qhov ntawm lawv. Tsis tas li ntawd, qhov tsis muaj cov ntaub so ntswg hematopoietic yog hloov los ntawm cov ntaub so ntswg adipose, uas nce mus txog 95%.
Ua rau pob txha pob txha aplasia hauv dev
Marrow aplasia hauv hom canine tuaj yeem tsim los ntawm cov laj thawj hauv qab no:
- Drugs: tshuaj kho mob tshuaj, azathioprine, trimethoprim/sulfadiazine, exogenous los yog endogenous estrogens, phenylbutazone, cephalosporins, phenothiazine, captopril los yog chloramphenicol.
- Environmental toxins: insecticide, benzol, varnish or paint.
- Microorganisms: Ehrlichia canis or canine parvovirus, which infects progenitor and proliferative cells in the bone marrow.
Ntxiv rau, ib qho congenital pure red cell aplasia hu ua Diamond-Blackfan anemia tau piav qhia hauv dev, uas cuam tshuam rau cov menyuam yaus. Nws ua rau tsis muaj erythroid precursors, tab sis lwm tus tsis zoo. Kuj tseem paub tias yog idiopathic lossis thawj aplasia, thaj chaw tiv thaiv kab mob, vim nws teb rau corticosteroid therapy.
Symptoms of bone marrow aplasia in dogs
Daim duab kho mob ntawm canine pob txha pob txha aplasia yuav sib txawv raws li qib ntawm kev koom tes ntawm tes, nrog rau tag nrho cov pancytopenia yuav hnyav dua, vim lawv yuav ua rau cov tsos mob ntsig txog qhov tsis muaj cov liab, dawb thiab platelet hlwb, nrog rau qhov no muaj rau tus dev cuam tshuam.
Cov tsos mob cuam tshuam nrog erythrocyte aplasia vim tsis muaj cov qe ntshav liab yog cov uas tau los ntawm ib qho anemia. Cov ntsiab lus tseem ceeb:
- Tachycardia.
- Tachypnea.
- Nyob.
- Nyob tsis muaj zog.
Thaum cov qe ntshav dawb, cov tshuaj tiv thaiv kab mob tiv thaiv kab mob, tsis muaj, tus dev yuav raug rau txhua yam kab mob.
Yog tias platelets ploj lawm, dev yuav muaj kev txom nyem hemorrhages, vim platelets koom nrog hauv coagulation ntawm cov ntshav. Cov hemorrhages no tuaj yeem ua rau me me, xws li qhov ncauj lossis qhov ntswg los ntshav, lossis, qhov phem tshaj plaws, lawv yuav tshwm sim hauv cov kab mob hauv nruab nrog cev, xws li lub plab zom mov lossis lub hlwb, ua rau tus dev txoj sia nyob.
Kev kuaj mob pob txha aplasia hauv canines:
Kev kuaj mob ntawm pob txha pob txha aplasia tau ua tiav nrog , uas tso cai rau cov qe ntshav liab thiab dawb thiab platelets mus raug soj ntsuam, uas nyob rau hauv tus kab mob no yuav ploj mus. Mob leukemias yuav tsum tau suav nrog hauv kev kuaj mob sib txawv.
Thaum qhov txo qis tau lees paub, bone marrow sample yuav tsum tau noj los ntawm kev xav lossis kev kuaj ntshav:
- Cov qauv Aspiration tso cai rau kev soj ntsuam ntawm tus kheej ntawm tes thiab kev txiav txim siab ntawm myeloid-erythroid ratio.
- Biopsy qhia cov qauv ntawm cov pob txha thiab nws lub ntiaj teb cellularity. Qhov no yog cov txheej txheem ntawm kev xaiv nyob rau hauv cov ntaub ntawv ntawm hypocellular marrow los yog marrow uas tau hloov los ntawm fatty ntaub so ntswg. Hauv cov qauv no, qhov tsis muaj cov hlwb hematopoietic yuav raug pom.
Bone marrow sample collection
Cov pob txha pob txha raug coj los ntawm cov dev ntawm qhov chaw hauv qab no:
- Paj huam sib luag ntawm humerus thiab femur.
- Iliac crest.
- Ilium wing.
- Rib.
Tshuaj pob txha aplasia hauv dev
Kev kho mob pob txha pob txha aplasia hauv dev yuav nyob ntawm seb hom cell cuam tshuam, tab sis, feem ntau, nws yog raws li hauv qab no:
- Tshuaj tua kab mob thiab asepsis nyob rau hauv cov mob leukocyte aplasia tiv thaiv kab mob sib kis.
- Stem cells, rau nws cov tshuaj tiv thaiv kab mob thiab tiv thaiv kab mob. Lawv yog lub luag hauj lwm rau repopulating pob txha pob txha vim lawv muaj peev xwm sib txawv rau hauv cov ntshav.
- Immunoglobulins
- Antilymphocyte los yog antifungal globulin.
- Cyclosporin A.
Kev mob pob txha aplasia hauv dev
Canine pob txha pob txha aplasia feem ntau muaj poor prognosis, vim nws yog ib tug pathology nyob rau hauv uas, nyob rau hauv ntau zaus, cov lus teb rau. kev kho mob tsis zoo. Yog li ntawd, nws tuaj yeem ua rau peb tus dev tuag, tshwj xeeb tshaj yog tias nws tsis tuaj yeem tiv thaiv kev tiv thaiv kab mob lossis keeb kwm ntawm cov pob txha aplasia tsis raug kuaj pom.
