kab mob Gumboro yog ib yam kab mob uas feem ntau cuam tshuam rau menyuam qaib ntawm thawj 3 thiab 6 lub lis piam ntawm lub neej. Nws kuj tseem tuaj yeem cuam tshuam rau lwm cov noog xws li ducks thiab qaib ntxhw, uas yog vim li cas nws yog ib qho ntawm cov kab mob ntau tshaj plaws hauv cov nqaij qaib. Tus kab mob no yog tus cwj pwm los ntawm kev cuam tshuam rau cov qog nqaij hlav hauv nruab nrog cev, nrog rau kev mob tshwj xeeb hauv bursa ntawm Fabricius hauv cov noog, ua rau kev tiv thaiv kab mob los ntawm kev cuam tshuam rau kev tsim cov tshuaj tiv thaiv kab mob. Tsis tas li ntawd, hom III hypersensitivity txheej txheem tshwm sim nrog kev puas tsuaj rau lub raum lossis cov hlab ntsha me me.
Cia nyeem tsab xov xwm no rau ntawm peb lub xaib kom paub meej Gumboro kab mob hauv cov noog yog dab tsi, nws cov tsos mob thiab kev kho mob.
kab mob Gumboro yog dab tsi?
Gumboro disease is a kab mob sib kis ntawm noog, kho mob cuam tshuam rau menyuam qaib hnub nyoog 3 txog 6 lub lis piam, tab sis nws tuaj yeem cuam tshuam rau qaib ntxhw thiab os. Nws yog tshwj xeeb yog atrophy thiab necrosis ntawm bursa ntawm Fabricius (ib lub cev lymphoid hauv cov noog uas yog lub luag haujlwm tsim cov B lymphocytes), uas ua rau muaj kev tiv thaiv kab mob hauv cov noog.
Nov yog ib yam kab mob ntawm kev noj qab haus huv thiab kev lag luam tseem ceeb uas cuam tshuam rau kev ua liaj ua teb qaib. Nws nthuav tawm qhov mob hnyav, kis ntawm 50 thiab 90% ntawm cov noog. Vim nws txoj kev tiv thaiv kab mob zoo heev, nws nyiam cov kab mob thib ob thiab cuam tshuam rau kev txhaj tshuaj.
Tus kab mob kis tau los ntawm kev sib cuag nrog cov quav ntawm cov qaib uas muaj kab mob los yog los ntawm dej, fomites thiab zaub mov kis los ntawm lawv.
Tus kab mob dab tsi ua rau Gumboro kab mob hauv cov noog?
kab mob Gumboro yog tshwm sim los ntawm avian infectious bursal disease, belongs to the family Birnaviridae and the genus Avibirnavirus. Nws yog ib tug kab mob resistant heev nyob rau hauv nruab nrab, rau qhov kub thiab txias, mus rau pH ntawm 2 thiab 12 thiab tshuaj tua kab mob.
Nws yog tus kab mob RNA uas muaj cov kab mob pathogenic, serotype I, thiab tsis muaj kab mob, serotype II. Serotype kuv suav nrog plaub tus kab mob:
- Maj thiab tshuaj tiv thaiv kab mob.
- Antigenic variants.
- Hypervirulent strains.
Pathogenesis of Gumboro disease in noog
Tus kab mob no nkag mus rau hauv qhov ncauj, mus txog txoj hnyuv uas nws rov ua dua hauv cov macrophages thiab T lymphocytes ntawm txoj hnyuv mucosa. Tom qab ntawd, first viremia (tus kab mob hauv cov ntshav) pib 12 teev tom qab kis kab mob. Nws kis mus rau daim siab qhov chaw uas nws rov ua dua hauv hepatic macrophages thiab tsis paub qab hau B lymphocytes hauv bursa ntawm Fabricius.
Tom qab cov txheej txheem saum toj no, thib ob viremia tshwm sim, tom qab ntawd rov ua dua hauv cov qog nqaij hlav hauv nruab nrog cev ntawm bursa ntawm Fabricius, thymus, spleen, mob qog nqaij hlav ntawm lub qhov muag thiab cecal tonsils. Qhov no ua rau kev puas tsuaj ntawm lymphoid hlwb, uas ua rau lub cev tsis muaj zog. Tsis tas li ntawd, hom 3 hypersensitivity tshwm sim nrog kev tso tawm ntawm kev tiv thaiv kab mob hauv lub raum thiab cov hlab ntsha me, ua rau nephromegaly thiab microthrombi, hemorrhages, thiab edema, raws li.
Gumboro kab mob cov tsos mob hauv cov noog
Hauv cov noog muaj ob hom kev kho mob tuaj yeem tshwm sim: subclinical thiab kho mob. Nyob ntawm qhov kev nthuav qhia, cov tsos mob ntawm tus kab mob Gumboro tuaj yeem sib txawv:
Subclinical form of Gumboro disease in noog
Daim ntawv subclinical tshwm sim nyob rau hauv me nyuam qaib qis dua 3 lub lis piam uas muaj kev tiv thaiv niam txiv qis. Hauv cov noog no muaj qhov hloov pauv tsawg thiab qhov nruab nrab txhua hnub nce, uas yog, vim lawv tsis muaj zog, lawv yuav tsum tau noj ntau dua tab sis, txawm li cas los xij, lawv tsis hnyav dua. Ib yam li ntawd, muaj kev haus dej ntau ntxiv, tiv thaiv kab mob thiab mob raws plab.
Clinical form of Gumboro disease in noog
Daim foos no tshwm sim hauv qaib 3 mus rau 6 lub lis piam, uas qhia cov tsos mob hauv qab no:
- Ua npaws.
- Pica.
- Ureter dilation.
Ntxiv rau, muaj qhov loj ntawm bursa ntawm Fabricius hauv thawj 4 hnub, tom qab congestion thiab hemorrhages tshwm sim los ntawm 4 mus rau 7 hnub thiab thaum kawg nws txo qhov loj vim atrophy thiab depletion. lymphoid, ua rau cov tshuaj tiv thaiv kab mob uas ua rau tus kab mob.
Diagnosis of Gumboro disease in noog
Kev kuaj mob yuav ua rau peb xav tias tus kab mob Gumboro, lossis kis kab mob bursitis, thaum muaj cov tsos mob zoo ib yam li cov menyuam yaus hnub nyoog 3 txog 6 lub lis piam, ua rau Differential Diagnosis nrog cov kab mob qaib hauv qab no:
- Avian infectious anemia.
- Marek's disease.
- Lymphoid leukosis.
- Avian Influenza.
- Newcastle disease.
- Avian infectious bronchitis.
- Avian coccidiosis.
Kev kuaj mob yuav ua tom qab rho tawm cov qauv thiab xa mus rau lub chaw soj nstuam kom ua tiav cov kev kuaj sim ncaj qha hauv kev tshawb nrhiav tus kab mob thiab kuaj tsis ncaj hauv kev tshawb nrhiav cov tshuaj tiv thaiv. Cov cov kev xeem ncaj nraim suav nrog:
- Viral cais.
- Immunohistochemistry.
- Antigen capture ELISA.
- RT-PCR.
The indirect proofs muaj xws li:
- AGP.
- Viral seroneutralization.
- Indirect ELISA.
Kho mob Gumboro kab mob hauv cov noog
Kev kho mob bursitis yog txwv. Vim yog kev puas tsuaj uas tshwm sim rau lub raum, ntau yam tshuaj yog contraindicated vim lawv cov kev phiv ntawm lub raum. Yog li ntawd, kev siv tshuaj tiv thaiv kab mob rau cov kab mob thib ob tuaj yeem ua tsis tau lawm niaj hnub no.
Vim tag nrho cov no, Tshuaj kho tsis tau rau kab mob Gumboro nyob rau hauv cov noog thiab kev tswj tus kab mob yuav tsum tau ua los ntawmkev ntsuas thiab kev ntsuas biosafety, xws li:
- Vaccination nrog cov tshuaj tiv thaiv kab mob nyob hauv cov tsiaj loj hlob 3 hnub ua ntej niam tsis muaj zog tiv thaiv kab mob, ua ntej cov tshuaj tiv thaiv no poob qis dua 200; los yog inactivated nyob rau hauv breeders thiab nteg hens kom muaj kev tiv thaiv leej niam rau yav tom ntej me nyuam qaib. Yog li, muaj tshuaj tiv thaiv kab mob Gumboro, tab sis tsis yog los tawm tsam nws thaum tus qaib tau kis, tab sis tiv thaiv nws los ntawm kev loj hlob.
- Tsev thiab tua kab mob ntawm teb los yog tsev.
- Control access to the farm.
- Kab Kab Tsuag nyob rau hauv pub thiab txaj uas muaj peev xwm nqa tau tus kab mob.
- Tiv thaiv lwm yam kab mob debilitating (mob anemia, marek, noj zaub mov tsis txaus, kev nyuaj siab…)
- Num, uas muaj kev sib cais cov me nyuam qaib los ntawm cov chaw sib txawv rau hauv cov chaw sib txawv. Piv txwv li, yog ib lub sanctuary cawm me nyuam qaib los ntawm ntau lub teb, nws yog qhov zoo dua kom cia lawv cais kom txog thaum lawv noj qab nyob zoo.
- Serological monitoring
NOJ QAB
