Dwarfism is the tsis muaj kev loj hlob hormone ntau lawm, kab mob tuaj yeem tshwm sim hauv dev. Nws yog ib qho txheej txheem uas tau kuaj pom thaum tus dev loj hlob thiab nws tau pom tias kev loj hlob tsis yog qhov nws yuav tsum ua raws li nws lub hnub nyoog thiab yug me nyuam. Tsis tas li ntawd, qhov tsis txaus ntawm lwm cov tshuaj hormones tuaj yeem tshwm sim nyob rau tib lub sijhawm uas ua rau lwm cov txheej txheem endocrine, xws li hypothyroidism lossis teeb meem kub hauv cov poj niam, nrog rau cov noob qes atrophy hauv cov txiv neej; Ntxiv nrog rau cov teeb meem dermatological thiab kab mob thib ob. Kev kuaj mob yog tsim los ntawm kev kuaj ntsuas thiab kev kho mob yog nrog cov tshuaj progestogens, txhawm rau txhawm rau nce cov tshuaj hormones.
Yog koj tsis tau pom ib tug dev uas muaj dwarfism, ntawm no yog ib daim duab ntawm ib tug neeg yug yaj German nrog dwarfism. Nyob ib sab ntawm no furry, lwm tus ntawm tib lub hnub nyoog tshwm sim, tab sis noj qab nyob zoo. Qhov tseeb, ob tus dev yog kwv tij los ntawm tib lub litter. Mus nyeem ntawv tsab xov xwm no rau ntawm peb qhov chaw hais txog dwarfism in dogs, ua, tsos mob thiab kev kho mob kom paub ntau ntxiv txog qhov teeb meem endocrine no uas tuaj yeem cuam tshuam rau peb cov dev.
Canine dwarfism yog dab tsi?
Dwarfism los yog pituitary dwarfism nyob rau hauv dev yog ib qho kab mob endocrine nyob rau hauv uas muaj qhov tsis txaus ntawm kev loj hlob hormone (GH) uas qee zaum tshwm sim ua ke. Nrog rau qhov tsis txaus ntawm cov tshuaj hormones tsim hauv hypothalamus, xws li TSH thiab prolactin.
Qhov no ua rau dwarfism los yog tsis muaj kev loj hlob zoo raws li lub hli dhau mus.
Ua dwarfism in dogs
This is a congenital disease: cov menyuam dev tau txais nws los ntawm lawv niam lawv txiv raws li tus qauv autosomal recessive qub txeeg qub teg.
Cov tsiaj txhu feem ntau zoo li yog German Shepherd, txawm hais tias nws tseem tuaj yeem pom hauv Weimaraner, Pinscher thiab Spitz.
Canine dwarfism tsos
Cov tsos mob ntawm pituitary dwarfism tshwm sim thaum cov dev mus txog hnub nyoog ob lossis peb lub hlis, ua ntej lawv zoo li cov menyuam dev. Txawm li cas los xij, txij li lub sijhawm no lawv tseem muaj menyuam dev cov plaub hau, tom qab ntawd lawv pib poob nws ua rau ob sab alopecia ntawm lub cev thiab nthuav tawm txo qis tab sis proportionate loj Ntxiv rau qhov dev nrog pituitary dwarfism nws tuaj yeem pom:
- Nkauj kho siab kaw lub suab nkauj kho siab.
- Fontanelles qhib ntev dua nyob rau hauv ib tug menyuam dev.
- Calcification of Penile pob txha.
- Nyob zoo cov hniav.
- Hyperpigmentation.
- Comedones thiab papules ntawm daim tawv nqaij.
- Cov kab mob kis kab mob thib ob ntawm daim tawv nqaij lossis kab mob ua pa.
- Hypothyroidism ntawm 2-3 xyoos ntawm lub neej.
- Cov kab mob qog nqaij hlav: anestrus (tsis muaj cua sov) hauv bitches thiab testicular atrophy hauv dev.
Txawm dwarfism tsis tuag nyob rau hauv nws tus kheej, nws ua txo qis lub neej expectancy kom tsawg dua 10 xyoo. Txawm li cas los xij, yog tias koj tus dev tsis loj hlob, nws yuav yog vim lwm yam, raws li peb piav qhia hauv lwm tsab xov xwm no vim li cas kuv tus dev tsis loj hlob?
Diagnosis of dwarfism in dogs
Kev kuaj mob ntawm pituitary dwarfism yog ua raws li kev kuaj mob thiab kuaj kuaj.
Differential Diagnosis
Cov kab mob sib txawv ntawm dwarfism hauv dev suav nrog kab mob hauv qab no:
- Hypoadrenocorticism.
- Iatrogenic hyperadrenocorticism.
- Juvenile diabetes.
- Nyob tsis taus.
- Portosystemic shunt.
- Gonadal dysgenesis.
- Kab mob pob txha.
- mob raum.
Clinical Diagnosis
Kev kuaj mob feem ntau yog ua raws li kev soj ntsuam ntawm kev txo qis ntawm tus dev raws li tus yam ntxwv ntawm nws cov tsiaj yug thiab hnub nyoog, uas feem ntau tuaj ua ke nrog lwm cov tsos mob uas peb tau hais, xws li teeb meem ntawm daim tawv nqaij.
Lab analyse
Cov tshuaj ntsuam xyuas yuav ua raws li
- Cell count and biochemistry: Cov ntshav suav thiab biochemistry hauv cov dev no feem ntau yog ib txwm muaj, txawm tias muaj hypophosphatemia, mob hypoalbuminemia, thiab hauv Qee zaum, tej zaum yuav muaj azotemia (nce creatinine lossis urea), vim tias qhov kev loj hlob hormone tsis txaus tuaj yeem cuam tshuam rau kev loj hlob ntawm lub raum glomeruli, uas yog lub luag haujlwm rau lim zis.
- Hommon Test: Cov tshuaj ntsuam xyuas cov thyroid hormone feem ntau cuam tshuam qhov nce ntawm T4 dawb thiab tag nrho tab sis tsis zoo li qhov xav tau hauv hypothyroidism uas yog nce TSH., hauv cov dev nrog dwarfism muaj qhov txo qis hauv TSH vim qhov tsis muaj kev tso tawm los ntawm hypothalamus hauv qhov teeb meem no.
- Insulin-like growth factor assay-Insulin-like growth factor-1 (IGF-1) assay yog txoj hauv kev zoo tshaj plaws los cuam tshuam tsis ncaj kev loj hlob hormone qhov tseem ceeb. Hauv cov dev uas muaj dwarfism qhov no tau txo qis, tsawg dua 50 ng / ml.
Lwm hom kev kuaj mob
Lwm txoj hauv kev kom mus txog qhov kev kuaj pom tseeb yog los ntawm kev txhawb kev loj hlob hormone tso tawm siv xylazine los yog GNRH Hauv cov tsiaj noj qab haus huv, kev loj hlob hormone yuav nce. Tom qab qhov kev tswj hwm no, txawm li cas los xij, hauv dwarfism qhov kev cuam tshuam no tsis tshwm sim.
Canine dwarfism yog kho nrog kev tswj hwm ntawm progestogens, xws li medroxyprogesterone, ntawm koob tshuaj 2.5-5 mg / kg txhua peb. lub lis piam hauv 6 koob tshuaj. Tom qab ntawd, yog tias tsim nyog, nws rov ua dua txhua 6 lub lis piam. Cov tshuaj no txhawb kev tsim cov tshuaj hormones loj hlob hauv cov qog mammary. Cov dev yuav tsum tau kuaj thiab kuaj txhua lub lim tiam , vim nws tuaj yeem ua rau acromegaly lossis ntshav qab zib. Feem ntau, cov tsos mob ntawm daim tawv nqaij txhim kho, cov plaub hau neeg laus hlob tuaj, thiab qhov hnyav nce.
Hnub no cov kev kho mob uas tau ua nrog bovine, porcine lossis tib neeg txoj kev loj hlob hormone poob siab, vim tias ntxiv rau muaj tus nqi siab, insulin tsis kam lossis hypersensitivity tuaj yeem tshwm sim. Kev tswj hwm cov thyroid hormones lossis glucocorticoids yuav tsum tau txiav txim siab, yog tias tsim nyog.
